Results 51 to 60 of about 14,336,962 (399)

Functional role and folding properties of the glucan‐binding domain of oral bacterial glucansucrase

FEBS Letters, EarlyView.
The role of the glucan‐binding domain in Streptococcus sobrinus glucansucrase was examined, focusing on its impact on enzymatic activity, dextran binding, and structural stability of deletion mutants and a circularly permuted protein. Our research revealed that glucosyl transfer efficiency is linked to cooperative interdomain folding.
Hideyuki Komatsu, Takayuki Sadakane, Yudai Murata, Junichi Taira, Hiroshi Sakamoto, Takao Kodama   +5 more
wiley   +1 more source

Highly Ionized Collimated Outflow from HE 0238 - 1904

, 2012
We present a detailed analysis of a highly ionized, multiphased and collimated outflowing gas detected through O V, O VI, Ne VIII and Mg X absorption associated with the QSO HE 0238 - 1904 (z_em ~ 0.629).
A. Narayanan, Arav, Asplund, B. D. Savage, Bentz, Bower, Crenshaw, Dai, Faucher-Giguère, Ferland, G. C. Dewangan, Ganguly, Gnat, Green, Gupta, Hall, Hamann, Hamann, Hamann, Hamann, King, Korista, Korista, Moos, Ojha, Onken, Osterman, Petitjean, Piconcelli, R. Srianand, S. Muzahid, Sahnow, Sambruna, Silk, Srianand, Stalin, Telfer, Telfer, V. Mohan, Verner, Vivek   +40 more
core   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Haplotypes encoding the factor VIII 1241Glu variation, factor VIII levels and the risk of venous thrombosis \ud \ud [PDF]

, 2006
Levels of factorVIII (FVIII) are associated with the risk of venous thrombosis.The FVIII variation D1241E has been reported to be associated with decreased levels of FVIII.
Bakker, Egbert, Bertina, Rogier M., Doggen, Carine J.M., Eikenboom, Jeroen C.J., Nossent, A.Yael, Rosendaal, Frits R., Tanis, Bea C., Vos, Hans L.   +7 more
core   +3 more sources

Murine coagulation factor VIII is synthesized in endothelial cells.

Blood, 2014
The primary cellular source of factor VIII (FVIII) biosynthesis is controversial, with contradictory evidence supporting an endothelial or hepatocyte origin.
L. Everett, Audrey C. A. Cleuren, R. Khoriaty, D. Ginsburg   +3 more
semanticscholar   +1 more source

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

Cyclosporine treatment of acquired hemophilia due to factor VIII antibodies [PDF]

, 2000
Acquired hemophilia, caused by autoantibodies against coagulation factor VIII, is usually treated with steroids, cyclophosphamide, intravenous gammaglobulins and sporadically other drugs.
Baele, Gaston, Derom, Eric, Petrovic, Mirko   +2 more
core  

Cosmic Origins Spectrograph Observations of Warm Intervening Gas Towards 3C263

, 2012
We present HST/COS high S/N observations of the z = 0.32566 multi-phase absorber towards 3C263. The COS data shows absorption from H I, O VI, C III, N III, Si III and C II. The Ne VIII in this absorber is detected in the FUSE spectrum.
Narayanan, Anand, Savage, Blair D., Wakker, Bart P.   +2 more
core   +1 more source

Molecular defects in coagulation Factor VIII and their impact on Factor VIII function [PDF]

Vox Sanguinis, 2002
Molecular defects in Factor VIII (FVIII), such as haemophilia A‐related mutations or denaturative conformational changes, may affect the stability of FVIII as well as its interactions with physiological activators, von Willebrand Factor, phospholipid, or conformationally sensitive antibodies.
Steven W. Pipe, Charlotte A. E. Hauser, Midori Shima, Djuro Josic, Horst Schwinn, Evgueni L. Saenko, Evgueni L. Saenko, Natalya M. Ananyeva, Diana Kouiavskaia   +8 more
openaire   +4 more sources

A conditional knockout mouse model reveals endothelial cells as the principal and possibly exclusive source of plasma factor VIII.

Blood, 2014
The cellular source of coagulation factor VIII (FVIII) remains controversial. Like many coagulation proteins, FVIII is produced in the liver, and FVIII synthesis has long been associated with hepatocytes.
S. Fahs, M. Hille, Q. Shi, H. Weiler, R. Montgomery   +4 more
semanticscholar   +1 more source