Results 61 to 70 of about 14,299,063 (394)

N-linked glycosylation modulates the immunogenicity of recombinant human factor VIII in hemophilia A mice

Haematologica, 2018
Immune responses to factor VIII remain the greatest complication in the treatment of severe hemophilia A. Recent epidemiological evidence has highlighted that recombinant factor VIII produced in baby hamster kidney cells is more immunogenic than factor ...
Jesse D. Lai, Laura L. Swystun, Dominique Cartier, Kate Nesbitt, Cunjie Zhang, Christine Hough, James W. Dennis, David Lillicrap   +7 more
doaj   +1 more source

Factor VIII activity and bleeding risk during prophylaxis for severe hemophilia A: a population pharmacokinetic model

Haematologica, 2020
During factor VIII prophylaxis for severe hemophilia A, bleeding risk increases with time when factor VIII activity is below 1%. Maintaining trough activity above 1% does not protect all patients from bleeding.
Andreas Tiede, Faraizah Abdul Karim, Victor Jiménez-Yuste, Robert Klamroth, Sandra Lejniece, Takashi Suzuki, Andreas Groth, Elena Santagostino   +7 more
doaj   +1 more source

User-Centered Design (VIII): A New Framework of Intelligent Sociotechnical Systems and Prospects for Future Human Factors Research [PDF]

arXiv, 2022
Traditional sociotechnical systems (STS) theory has been widely used, but there are many new characteristics in the STS environment as we enter the intelligence era, resulting in the limitations of traditional STS. Based on the "user-centered design" philosophy, this paper proposes a new framework of intelligent sociotechnical systems (iSTS) and ...
arxiv  

Acquired hemophilia A in the setting of dual anticoagulation therapy and lupus anticoagulant: a case report

Journal of Medical Case Reports, 2022
Background Acquired hemophilia A is a disorder caused by autoantibodies against coagulation factor VIII that may present with severe bleeding. We report a rare case of acquired hemophilia A presenting with coexisting lupus anticoagulant.
Victor Chen, Lauren C. Roby, Stephanie Wentzel, Mingjia Li, Nicholas Jones   +4 more
doaj   +1 more source

Cos observations of metal line and broad lyman alpha absorption in the multi-phase o vi and ne viii system toward he 02226-4110 [PDF]

, 2011
Observations of the QSO HE 0226-4110 (zem = 0.495) with the Cosmic Origins Spectrograph (COS) from 1134 to 1796 {\AA} with a resolution of ~17 km s-1 and signal-to- noise (S/N) per resolution element of 20 to 40 are used to study the multi-phase absorption system at z = 0.20701 containing O VI and Ne VIII. The system was previously studied with lower S/
arxiv   +1 more source

Imbalance of pro- vs. anti-coagulation factors in Chinese patients with Budd-Chiari syndrome and non-cirrhotic portal vein thrombosis. [PDF]

PLoS ONE, 2015
The coagulation abnormalities in non-cirrhotic Budd-Chiari syndrome (NC-BCS) and non-cirrhotic portal vein thrombosis (NC-PVT) are unclear. We conducted this case-control study to investigate the coagulation profile of NC-BCS and NC-PVT in Chinese ...
Hui Chen, Lei Liu, Xingshun Qi, Chuangye He, Zhanxin Yin, Feifei Wu, Daiming Fan, Guohong Han   +7 more
doaj   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Immunogenicity of Current and New Therapies for Hemophilia A

Pharmaceuticals, 2022
Anti-drug antibody (ADA) development is a significant complication in the treatment of several conditions. For decades, the mainstay of hemophilia A treatment was the replacement of deficient coagulation factor VIII (FVIII) to restore hemostasis, control,
Alessandra N. L. Prezotti, Jéssica O. Frade-Guanaes, Gabriela G. Yamaguti-Hayakawa, Margareth C. Ozelo   +3 more
doaj   +1 more source

Elastic Form Factors in Point-form Approach [PDF]

, 2000
Using the point-form approach to relativistic quantum mechanics, a covariant framework is presented for the calculation of proton and neutron electromagnetic form factors. Results for charge radii, magnetic moments, and electric as well as magnetic form factors are produced using the wave functions obtained in the so-called Goldstone-boson-exchange ...
arxiv   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source