Results 1 to 10 of about 19,832,698 (194)

Human hepatoma cells secrete single chain factor X, prothrombin, and antithrombin III [PDF]

Blood, 1984
DS Fair, BR Bahnak
semanticscholar   +4 more sources

The X factor in neurodegeneration

Journal of Experimental Medicine, 2022
Given the aging population, it is important to better understand neurodegeneration in aging healthy people and to address the increasing incidence of neurodegenerative diseases. It is imperative to apply novel strategies to identify neuroprotective therapeutics.
Rhonda Voskuhl, Yuichiro Itoh
openaire   +2 more sources

Factor X Deficiency [PDF]

American Society for Clinical Laboratory Science, 2010
1. Dorothy M (Adcock) Funk, M.D.[⇑][1] 1. Esoterix Coagulation, 8490 Upland Drive, Ste.100, Englewood, CO 80112 2. Dennis Casciato, M.D. 1. David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1732 1. Address for Correspondence: Dorothy M (Adcock) Funk, M.D., Esoterix Coagulation, 8490 Upland Drive, Ste.100, Englewood, CO ...
Dennis A. Casciato, Dorothy M (Adcock) Funk   +1 more
openaire   +2 more sources

The X factor [PDF]

Nature, 2005
The sequence of the ‘feminine’ X chromosome is a prime hunting ground for geneticists interested in the evolution of the cognitive and cultural sophistication that defines the human species. Erika Check reports.
openaire   +4 more sources

Myeloid cell–synthesized coagulation factor X dampens antitumor immunity

Science immunology, 2019
Rivaroxaban, an inhibitor of coagulation factor Xa, promotes antitumor immunity in mice. Targeting factor Xa to promote antitumor immunity Secreted molecules including cytokines regulate immune cell functions in the tumor microenvironment (TME).
C. Graf, P. Wilgenbus, Sven Pagel, Jennifer Pott, F. Marini, S. Reyda, Maki Kitano, S. Macher-Göppinger, H. Weiler, W. Ruf   +9 more
semanticscholar   +1 more source

The role of emicizumab, a bispecific factor IXa- and factor X-directed antibody, for the prevention of bleeding episodes in patients with hemophilia A

Therapeutic Advances in Hematology, 2018
Hemophilia A, characterized by impaired or absent expression of factor VIII, has long been managed via direct factor replacement. Functionally, factor VIII acts as a cofactor for factor IXa and allows activation of factor X, which, in combination with ...
Tristan E. Knight, M. Callaghan
semanticscholar   +1 more source

Efficacy, safety and pharmacokinetics of a new high‐purity factor X concentrate in women and girls with hereditary factor X deficiency

Journal of Thrombosis and Haemostasis, 2018
Essentials Plasma‐derived factor X concentrate (pdFX) is used to treat hereditary factor X deficiency. pdFX pharmacokinetics, safety and efficacy were assessed in factor X‐deficient women/girls.
R. Kulkarni, Andra H. James, M. Norton, A. D. Shapiro   +3 more
semanticscholar   +1 more source

Efficacy, safety and pharmacokinetics of a new high‐purity factor X concentrate in subjects with hereditary factor X deficiency

Haemophilia, 2016
Hereditary factor X (FX) deficiency is a rare bleeding disorder affecting 1:500 000 to 1:1 000 000 of individuals. Until recently, no specific replacement factor concentrate was available.
Steve Austin, K. Kavaklı, M. Norton, F. Peyvandi, A. Shapiro   +4 more
semanticscholar   +1 more source

Aetiology: The X factor [PDF]

Nature, 2012
Researchers have plenty of theories about what might cause multiple sclerosis. But for now, the factor that triggers the disease remains elusive.
openaire   +2 more sources

Heparanase enhances the generation of activated factor X in the presence of tissue factor and activated factor VII

Haematologica, 2010
Background Heparanase is an endo-β-D-glucuronidase dominantly involved in tumor metastasis and angiogenesis. Recently, we demonstrated that heparanase is involved in the regulation of the hemostatic system.
Y. Nadir, B. Brenner, L. Fux, I. Shafat, J. Attias, I. Vlodavsky   +5 more
semanticscholar   +1 more source