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A viable mouse model of factor X deficiency provides evidence for maternal transfer of factor X

open access: yesJournal of Thrombosis and Haemostasis, 2008
Summary.  Background: Activated factor X (FXa) is a vitamin K‐dependent serine protease that plays a pivotal role in blood coagulation by converting prothrombin to thrombin.
S. J. Tai   +7 more
semanticscholar   +1 more source

The Conformational Switch from the Factor X Zymogen to Protease State Mediates Exosite Expression and Prothrombinase Assembly*

open access: yesJournal of Biological Chemistry, 2008
Zymogens of the chymotrypsin-like serine protease family are converted to the protease state following insertion of a newly formed, highly conserved N terminus. This transition is accompanied by active site formation and ordering of several surface loops
R. Toso, Hua Zhu, R. Camire
semanticscholar   +1 more source

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