Results 11 to 20 of about 26,876,546 (349)

Blood coagulation factor X: molecular biology, inherited disease, and engineered therapeutics. [PDF]

J Thromb Thrombolysis, 2021
Camire RM.
europepmc   +4 more sources

A viable mouse model of factor X deficiency provides evidence for maternal transfer of factor X. [PDF]

Journal of Thrombosis and Haemostasis, 2008
BackgroundActivated factor X (FXa) is a vitamin K-dependent serine protease that plays a pivotal role in blood coagulation by converting prothrombin to thrombin. There are no reports of humans with complete deficiency of FX, and knockout of murine F10 is
Arruda, VR, Chu, K, Golden, JA, Herzog, RW, High, KA, Labosky, PA, Margaritis, P, Tai, SJ   +7 more
core   +3 more sources

Heparanase enhances the generation of activated factor X in the presence of tissue factor and activated factor VII

Haematologica, 2010
Background Heparanase is an endo-β-D-glucuronidase dominantly involved in tumor metastasis and angiogenesis. Recently, we demonstrated that heparanase is involved in the regulation of the hemostatic system.
Yona Nadir, Benjamin Brenner, Liat Fux, Itay Shafat, Judith Attias, Israel Vlodavsky   +5 more
doaj   +2 more sources

Severe Congenital Factor X Deficiency as a First Case Report in Cambodia [PDF]

Case Reports in Hematology
Conclusion: FX deficiency, though rare, should be considered in the differential diagnosis of pediatric patients presenting with recurrent gingival or mucocutaneous bleeding in conjunction with prolonged PT and APTT.
Chin Soey, Meang Sovandos, Lam Pechkethia, Lean Kimsreng, Chean Sophâl   +4 more
doaj   +2 more sources

Factor X deficiency: An overlooked cause of bleeding in the newborn [PDF]

Asian Journal of Transfusion Science
Inherited factor X (FX) deficiency is a rare autosomal recessive bleeding disorder, presenting with various bleeding manifestations ranging from nonspecific bruising to life-threatening intracranial hemorrhage.
Shalini Verma, Shalini Tripathi, Mala Kumar   +2 more
doaj   +2 more sources

A Rare Cause of Acquired Factor X Deficiency in an 87-Year-Old Female [PDF]

Case Reports in Hematology, 2021
Factor X deficiency is a rare coagulopathy that can be inherited or acquired. Acquired factor X deficiency has been associated with plasma cell dyscrasias, amyloids, and use of vitamin K antagonists.
Ayrton Bangolo, Trupti Waykole, Bilal Niazi, Chandini Sajja, Mahabuba Akhter, Bhavna Gupta, Sameh Elias   +6 more
doaj   +2 more sources

PB2326: SAFE AND EFFECTIVE PROPHYLAXIS WITH PLASMA-DERIVED FACTOR X CONCENTRATE IN AN ELDERLY PATIENT WITH HEREDITARY FACTOR X DEFICIENCY [PDF]

HemaSphere, 2022
H. Patel, S. Peltier, K. Clark, M. T. Reding   +3 more
doaj   +2 more sources

Impaired factor X and prothrombin activation associated with decreased phospholipid exposure in platelets from a patient with a bleeding disorder [PDF]

Blood, 1985
Jan Rosing, EM Bevers, Paul Comfurius, H.C. Hemker, G. van Dieijen, HJ Weiss, RF Zwaal   +6 more
openalex   +2 more sources

Evaluation of Clinical Features, Laboratory Findings and Treatment of Patients with Rare Factor Deficiency: A Retrospective Single Center Experience

Çocuk Dergisi, 2023
Objective: Patients with a rare factor deficiency (RFD) may be asymptomatic or present with life-threatening bleeding. Studies have shown no direct relationship between factor activity level and bleeding severity, with difficulties being experienced in ...
Işık Odaman Al, Tuba Hilkay Karapınar, Salih Gözmen, Yeşim Oymak   +3 more
doaj   +1 more source

The X factor in neurodegeneration

Journal of Experimental Medicine, 2022
Given the aging population, it is important to better understand neurodegeneration in aging healthy people and to address the increasing incidence of neurodegenerative diseases. It is imperative to apply novel strategies to identify neuroprotective therapeutics.
Rhonda Voskuhl, Yuichiro Itoh
openaire   +2 more sources