Results 31 to 40 of about 9,057,173 (269)

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

The Median Largest Prime Factor

, 2013
Let $M(x)$ denote the median largest prime factor of the integers in the interval $[1,x]$. We prove that $$M(x)=x^{\frac{1}{\sqrt{e}}\exp(-\text{li}_{f}(x)/x)}+O_{\epsilon}(x^{\frac{1}{\sqrt{e}}}e^{-c(\log x)^{3/5-\epsilon}})$$ where $\text{li}_{f}(x ...
Naslund, Eric
core   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

FEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi, Yuka Hirosawa, Yusaku Sagisaka, Minami Hama, Satoshi Takeda, Jun A. Komano   +5 more
wiley   +1 more source

Fermion to Boson Mapping

, 2005
The enveloping algebra,$D_{n}$,of fermions is extended on the lattice to include the discrete space invariance.This extended algebra,denoted X, has the space symmetry as a factor : $X/D_{n}$ = space ...
Asis Basu, Barisic, Belyaev, Brazovskii, Campbell, Chakrabarti, Chakrabarti, Creutz, Gambhir, Gogolin, Haldane, Haldane, Holstein, Janssen, Jayprokas Chakrabarti, Klein, Kronig, Lipkin, Luttinger, Marshalek, Marumori, Mattis, Okubo, Onodera, Ovchinnikov, Rice, Sawada, Schultz, Smit, Sorensen, Su, Takayama, Tomonaga, Ya Krivnov, Zabrodin, Zhang   +35 more
core   +1 more source

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

Polarization Dependence of Anomalous X-ray Scattering in Orbital Ordered Manganites

, 1998
In order to determine types of the orbital ordering in manganites, we study theoretically the polarization dependence of the anomalous X-ray scattering which is caused by the anisotropy of the scattering factor.
A. Kirfel, A. V. Kolpakov, B. J. Sternlieb, C. H. Chen, D. H. Templeton, D. H. Templeton, E. O. Wollan, E. Tsuji, G. Matsumoto, H. Kawano, H. Shiba, J. B. Goodenough, J. Kanamori, K. Chahara, K. I. Kugel, M. Blume, M. Fabrizio, M. Imada, P. G. Radaeli, R. Maezono, R. Shiina, R. von Helmolt, S. Ishihara, S. Ishihara, S. Ishihara, S. Ishihara, S. Ishihara, S. Jin, Sadamichi Maekawa, Sumio Ishihara, T. Mizokawa, T. Mizokawa, T. Nagano, T. Saitoh, V. E. Dmitrienko, W. Koshibae, W. Koshibae, Y. Ito, Y. Murakami, Y. Murakami, Y. Tokura, Z. Jirak   +41 more
core   +1 more source

TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation

FEBS Letters, EarlyView.
TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling, Kodi Hunter, Celest W. S. Tay, Nicola T. Wood, Philip Cohen   +4 more
wiley   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source