Results 91 to 100 of about 989,774 (270)

Factor X Concentrate Treatment Schedule and Dosing in Acquired FX Deficiency

Hematology Reports
Background: Acquired factor X (FX) deficiency is a rare condition that can cause life threatening bleeding. Here we outline a successful management strategy for gastrointestinal bleeding (GI) using human FX concentrate.
Andrew Ross, Rebecca J. Shaw, Louise Garth, Cathy Farrelly   +3 more
doaj   +1 more source

A Case of Haemorrhages caused by Multiple Myeloma Induced Factor Deficiencies: A Bleeding Enigma [PDF]

Journal of Clinical and Diagnostic Research
A 74-year-old male patient presented with anaemia, thrombocytopenia, and extensive haemorrhages over both thighs and back. A coagulation work-up revealed markedly elevated Prothrombin Time (PT) and activated Partial Thromboplastin Time (aPTT).
Abhijith Lakshman, Febe Renjitha Suman, Gramani Arumugam Vasugi, Uma Lakshmi Ramdoss   +3 more
doaj   +1 more source

Vitamin D, a modulator of musculoskeletal health in chronic kidney disease [PDF]

, 2017
The spectrum of activity of vitamin D goes beyond calcium and bone homeostasis, and growing evidence suggests that vitamin D contributes to maintain musculoskeletal health in healthy subjects as well as in patients with chronic kidney disease (CKD ...
Jordi Bover, Juan J. Carrero, null null, Pablo Molina, Pablo Ureña Torres, Philippe Chauveau, Sandro Mazzaferro   +6 more
core   +2 more sources

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

FACTOR-X DEFICIENCY: A RARE DISORDER TO BE LOOKED FOR IN CASES OF CONGENITAL BLEEDING TENDENCY [PDF]

Khyber Medical University Journal, 2018
Factor X deficiency is a rare, autosomal recessive disorder that involves the coagulation cascade. People with this disorder present with a myriad of early life bleeding complications.
Fatima Ayaz, Saeed Bin Ayaz, Muhammad Furrukh   +2 more
doaj  

Identification of eight novel coagulation factor XIII subunit A mutations: implied consequences for structure and function

Haematologica, 2010
Background Severe hereditary coagulation factor XIII deficiency is a rare homozygous bleeding disorder affecting one person in every two million individuals. In contrast, heterozygous factor XIII deficiency is more common, but usually not associated with
Vytautas Ivaskevicius, Arijit Biswas, Carville Bevans, Verena Schroeder, Hans Peter Kohler, Hannelore Rott, Susan Halimeh, Petro E. Petrides, Harald Lenk, Manuele Krause, Bruno Miterski, Ursula Harbrecht, Johannes Oldenburg   +12 more
doaj   +1 more source

Biotin Supplementation Ameliorates Murine Colitis by Preventing NF-κB Activation. [PDF]

, 2020
Background & aimsBiotin is a water-soluble vitamin that is indispensable for human health. Biotin deficiency can cause failure-to-thrive, immunodeficiency, alopecia, dermatitis, and conjunctivitis.
Cahalan, Michael D, Hwang, Michael, Nakasaki, Manando, Sabui, Subrata, Said, Hamid M, Skupsky, Jonathan   +5 more
core  

Deficits in trabecular bone microarchitecture in young women with Type 1 diabetes mellitus [PDF]

, 2015
Context: The pathophysiological mechanism of increased fractures in young adults with Type 1 Diabetes Mellitus (T1DM) is unclear. Objective: Case:control study of trabecular bone microarchitecture and vertebral marrow adiposity in young women with ...
Al-Daghri, Almeida, Amiel, Baroncelli, Baxter, Benjamin, Bereket, Botolin, Bredella, Bredella, Brismar, Chamberlain, Dai, Dhaliwal, Donaldson, Dunger, Fazeli, Fazeli, Forsén, Genant, Gevers, Giustina, Goettsch, Govan, Guler, Hothersall, Issever, Justesen, Kawai, Li, Martin, McComb, Menagh, Miller, Naressi, Neumann, Nicodemus, Patsch, Qvist, Rosen, Santos, Schellinger, Shen, Slade, Svoren, Vanhamme, Vestergaard, Wagegg, Wędrychowicz, Zemel   +49 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Mitochondrial fatty acid oxidation is stimulated by red light irradiation

FEBS Letters, EarlyView.
Light at different wavelengths has distinct effects on keratinocyte viability and metabolism. UVA light abrogates metabolic fluxes. Blue and green light have no effect on metabolic fluxes, while red light enhanced oxidative phosphorylation by promoting fatty acid oxidation. Keratinocytes are the primary constituents of sunlight‐exposed epidermis.
Manuel Alejandro Herrera, Camille C. Caldeira da Silva, Maiza Von Dentz, Mauricio S. Baptista, Alicia J. Kowaltowski   +4 more
wiley   +1 more source