Results 71 to 80 of about 10,192,906 (282)
Factor X Concentrate Treatment Schedule and Dosing in Acquired FX Deficiency
Hematology ReportsBackground: Acquired factor X (FX) deficiency is a rare condition that can cause life threatening bleeding. Here we outline a successful management strategy for gastrointestinal bleeding (GI) using human FX concentrate.
Andrew Ross +3 more
doaj +1 more source
Mutations in Indian patients of Factor X deficiency.
, 2014 §Novel variations.Mutations in Indian patients of Factor X deficiency.
Shrimati D. Shetty (566739) +7 more
core +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Factor X Deficiency: A Rare Case of Inherited Coagulation Disorder Presenting As Hemarthrosis [PDF]
, 2014 Hemophilia due to factor VIII deficiency is most common inherited bleeding disorder in paediatric population. Hemarthrosis is initial manifestation in large number of patients.
Barik, Sumit, Sinha, Sweta
core +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Acquired factor X deficiency in systemic amyloidosis
Cleveland Clinic Journal of Medicine, 1987 Acquired factor X deficiency has been described in association with primary amyloidosis in a small number of patients. Although readily corrected in vitro by mixing patient plasma with normal plasma, the deficiency is not easily corrected in vivo because transfused factor X is rapidly cleared from the circulation.
F V, Lucas +4 more
openaire +2 more sources
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Isolated Factor X Deficiency as an Immune-Mediated Complication of Waldenström Macroglobulinemia
Journal of Human ImmunityUnexplained coagulopathy with persistent anemia presents a significant diagnostic challenge and requires a broad differential. Isolated coagulation factor deficiencies are uncommon and described only sporadically in the literature.
Divakara Gouda +3 more
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source