Results 41 to 50 of about 18,017 (247)

7-Fluoroindazoles as Potent and Selective Inhibitors of Factor Xa

, 2016
We have developed a novel series of potent and selective factor Xa inhibitors that employ a key 7-fluoroindazolyl moiety. The 7-fluoro group on the indazole scaffold replaces the carbonyl group of an amide that is found in previously reported factor Xa ...
Tianbao Lu (2457745), Daniel J. Parks (2457733), Bruce E. Maryanoff (1878442), Bruce P. Damiano (2332213), Yu-Kai Lee (2457736), Mark R. Player (2143573), Thomas Markotan (2457742), Wenxi Pan (2065681), Nisha Ninan (2457748), Edward C. Giardino (2457739), David F. McComsey (2183138), Marta C. Abad (2183132), Tho V. Thieu (2125486), Carl S. Crysler (2143555), Karen L. Milkiewicz (2457751)   +14 more
core   +1 more source

Binder Engineering Suppresses Jahn–Teller‐Driven Mn Dissolution and Enables High‐Loading MnO2 Cathodes for Aqueous Zn‐Ion Batteries

Advanced Functional Materials, EarlyView.
A Zn2+‐coordinated poly(vinylidene fluoride) binder is shown to suppress Jahn–Teller‐driven Mn dissolution while improving dispersion, wettability, and structural integrity in thick MnO2 cathodes. This simple binder‐engineering strategy enables high‐loading aqueous Zn‐ion batteries with enhanced areal capacity, cycling stability, and practical promise ...
Insung Jang, Geun Yoo, Geon−Hyoung An
wiley   +1 more source

Factor Xa inhibitors for preventing recurrent thrombosis in patients with antiphospholipid syndrome : a longitudinal cohort study [PDF]

, 2019
Objective The objective of this study was to clarify the efficacy and safety of factor Xa inhibitors for antiphospholipid syndrome patients in real world utilization. Methods This is a retrospective cohort study comprised of all consecutive patients with
Yasuda, S., Kato, M., Bohgaki, T., Sato, T., Ohnishi, N., Oku, K., Amengual, O., Abe, N., Kono, M., Atsumi, T., Fujieda, Y., Nakamura, H.   +11 more
core   +1 more source

SPECIFIC ANTIDOTES TO NEW ORAL ANTICOAGULANTS

Атеротромбоз, 2016
Safety profiles of the novel oral anticoagulants (NOAC) (rivaroxaban, apixaban, edoxaban,  dabigatran) are better than that of warfarin. However, the risk (including lifethreatening) of bleeding  is no less than 2.3–3.1% per year.
O. O. Shakhmatova
doaj   +1 more source

Microfabricated Anisotropic Myobundles for the Scalable Production of Cardiac Tissue Grafts

Advanced Functional Materials, EarlyView.
Controlling the anisotropy of cardiac tissue remains an outstanding challenge in the field of cardiac tissue engineering. Here, we introduce an approach to generate anisotropic cardiac myobundles using cell‐adhesive, synthetic, electrospun fibers and stem cell‐derived cardiac fibroblasts.
Maggie E. Jewett, Javiera Jilberto, Margaret E. Stanley, David O. Ntim, Siddhi M. Bhirud, Avianna T. Schroeder, Gonzola X. Anyosa Galvez, Jingyi Xia, Samuel J. DePalma, Emmanouil Agrafiotis, Susan S. Xi, Amanda S. Bluem, Courtney M. Lestock, Adam S. Helms, David A. Nordsletten, Brendon M. Baker   +15 more
wiley   +1 more source

Direct thrombin inhibitors and factor Xa inhibitors for atrial fibrillation

, 2017
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the effectiveness of direct thrombin inhibitors and factor Xa inhibitors on clinical outcomes in patients with ...
Tracy W Tai, Heneghan, CJ, Mahtani, KR, Mahtani, Kamal, Kamal R Mahtani, Heneghan, Carl, Carl J Heneghan, Tai, TW   +7 more
core   +1 more source

Lyophilized Synthetic Platelets: In Vitro Characterization and in Vivo Evaluation in Mouse Thrombocytopenia Model

Advanced Science, EarlyView.
ABSTRACT Platelet transfusions to treat bleeding complications use donor‐derived platelets stored at room‐temperature, that have a shelf‐life of only 5–7 days due to bacterial contamination risks. Cold‐stored and freeze‐dried platelets are being investigated for extending shelf‐life, but these still have the inherent challenge of donor‐dependency.
Ujjal Didar Singh Sekhon, Dante Disharoon, Shrijal S. Desai, Baylee Traylor, Emily Gahagan, Emma Quill, Kristin Aldridge, Norman F. Luc, Sonali Rohiwal, Shruti Raghunathan, Rebecca Ahn, Sana Syed, Alexander Dornback, Bipin Chakravarthy Paruchuri, Andrew Ditto, Susan M. Shea, Philip C. Spinella, Matthew D. Neal, Michael A. Bruckman, Christa L. Pawlowski, Anirban Sen Gupta   +20 more
wiley   +1 more source

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

Inhibition of factor Xa and trypsin by tetrapeptide inhibitors.

, 2013
Inhibition of factor Xa and trypsin by tetrapeptide inhibitors.
Sheuli Zakia (328736), Pedro J. B. Pereira (116034), Julian Gingold (328737), Ana C. Figueiredo (328735), Manfred Philipp (328738), Cristina C. Clement (251207)   +5 more
core   +1 more source

T Cell‐Independent Role of PD‐L1 in Kidney Repair: Mitigation of Tubular DNA Damage via PD‐L1/BRCA1 Interaction Following AKI

Advanced Science, EarlyView.
PD‐L1 is primarily expressed in renal tubules and upregulated in both murine models of AKI and renal biopsy samples from patients with AKI. PD‐L1 can promote adaptive TECs repair through interacting with BRCA1, independent of its canonical immunomodulatory function of T cells, and PD‐L1 supplementation may represent a promising therapeutic strategy for
Wei Jiang, Tao‐Tao Tang, Wei‐Jie Ni, Jin‐Xuan Wei, Liang‐Yun‐Zi Jiang, Qing Yin, Yi‐Lin Zhang, Zuo‐Lin Li, Yi Wen, Xin‐Lu Wang, Jun‐Yuan Shen, Xiao‐Jun Ouyang, Ming‐Zhu Zheng, Jian Xu, Xiaofei An, Lin‐Li Lv, Bi‐Cheng Liu, Bin Wang   +17 more
wiley   +1 more source