Results 41 to 50 of about 4,655,222 (236)

Gla-domainless factor Xa: molecular bait to bypass a blocked tenase complex

Haematologica, 2012
Background Hemophilia is caused by deficiencies in coagulation factor VIII or IX, resulting in direct blockade of the intrinsic tenase complex and indirect blockade of the extrinsic tenase complex which is rapidly inhibited upon binding of factor Xa to ...
Raphaël Marlu, Benoît Polack
doaj   +1 more source

Use of non-vitamin K antagonists oral anticoagulants in atrial fibrillation patients on dialysis

Frontiers in Cardiovascular Medicine, 2022
BackgroundNon-vitamin K antagonist oral anticoagulants (NOACs) showed a benefit-risk profile superior to that of warfarin in atrial fibrillation (AF) patients with mild to moderate chronic kidney disease. However, the effectiveness and safety of NOACs in
Wenhao Li, Yanxia Zhou, Siqi Chen, Dewang Zeng, Haidong Zhang   +4 more
doaj   +1 more source

Andexanet alfa - what we know about this promising drug

Journal of Education, Health and Sport, 2023
Introduction and purpose. Andexanet alfa (AA) is a recombinant modified version of human activated factor X. It is used as an antidote for apixsaban and rivaroxaban when reversal of anticoagulation due to life-threatening or uncontrolled bleeding is ...
Natalia Ilnicka, Patrycja Zuziak, Maria Sadlik, Daria Matyja, Leila Abod   +4 more
doaj   +1 more source

Reversal of Oral Anticoagulants: A Survey of Contemporary Practice Trends (ReACT)

Clinical and Applied Thrombosis/Hemostasis, 2023
This study evaluated practice patterns and factors influencing treatment decisions regarding urgent or emergent reversal of oral anticoagulants (OACs). A 30-question survey was electronically distributed to anticoagulation members of the Anticoagulation ...
Huiwen Deng PharmD, MPH, Edith A. Nutescu PharmD, MS CTS, FCCP, Robert J. DiDomenico PharmD, FCCP, FHFSA, FACC   +2 more
doaj   +1 more source

Synthesis, Docking, and In Vitro Anticoagulant Activity Assay of Hybrid Derivatives of Pyrrolo[3,2,1-ij]Quinolin-2(1H)-one as New Inhibitors of Factor Xa and Factor XIa

Molecules, 2020
Coagulation factor Xa and factor XIa are proven to be convenient and crucial protein targets for treatment for thrombotic disorders and thereby their inhibitors can serve as effective anticoagulant drugs.
Nadezhda Novichikhina, Ivan Ilin, Anna Tashchilova, Alexey Sulimov, Danil Kutov, Irina Ledenyova, Mikhail Krysin, Khidmet Shikhaliev, Anna Gantseva, Ekaterina Gantseva, Nadezhda Podoplelova, Vladimir Sulimov   +11 more
doaj   +1 more source

Diblock Copolymer Nanoparticles Act as Nanoreactors for the Synthesis of Sterically‐Stabilized Inorganic Oxide Particles in Non‐polar Media

Angewandte Chemie, EarlyView.
Poly(lauryl methacrylate)‐poly(2‐hydroxyethyl methacrylate) (PLMA‐PHEMA) diblock copolymer nanoparticles prepared in non‐polar media serve as nanoreactors for the in situ synthesis of silica from tetraethyl orthosilicate (TEOS). A silica mass loading of 17% as judged by thermogravimetric analysis (TGA) produces a highly transparent dispersion, and ...
Priyanka Chohan, Andi Xie, Oleksandr O. Mykhaylyk, Steven P. Armes, Giles M. Prentice, David J. Atkinson, Andrew J. Smith   +6 more
wiley   +2 more sources

Structural Basis for Inhibition Promiscuity of Dual Specific Thrombin and Factor Xa Blood Coagulation Inhibitors [PDF]

, 2001
Background: A major current focus of pharmaceutical research is the development of selective inhibitors of the blood coagulation enzymes thrombin or factor Xa to be used as orally bioavailable anticoagulant drugs in thromboembolic disorders and in the ...
Wienen, Wolfgang, Angela Schmid, Wolfgang Wienen, Iris K Kauffmann, Kauffmann, Iris K, Jean-Marie Stassen, Ries, Uwe J, Hauel, Norbert H, Herbert Nar, Henning W.M Priepke, Nar, Herbert, Stassen, Jean-Marie, Bauer, Margit, Norbert H Hauel, Uwe J Ries, Schmid, Angela, Priepke, Henning W.M, Margit Bauer   +17 more
core   +1 more source

Bleeding Risk in Nonvalvular Atrial Fibrillation Patients Receiving Direct Oral Anticoagulants and Warfarin: A Systematic Review and Meta-Analysis of Observational Studies

TH Open, 2020
Introduction In randomized trials in atrial fibrillation (AF) patients on direct oral anticoagulants (DOACs) have a lower risk of bleeding compared with warfarin. However, data from randomized trials may not extrapolate to general population. We aimed to
Yimin Pearl Wang, Rohan Kehar, Alla Iansavitchene, Alejandro Lazo-Langner   +3 more
doaj   +1 more source

Defined Dinuclear Nickel Sites on Mesoporous Silica Translate Molecular Surface Mimics to Heterogeneous Catalysis

Angewandte Chemie, EarlyView.
The cooperative reactivity characteristic of molecular dinuclear nickel complexes is transferred to mesoporous silica through a systematic immobilization strategy. The resulting material preserves the key features of the bimetallic motif within a robust heterogeneous framework, demonstrating how molecular design principles can be translated into well ...
Jitpisut Poolwong, Adrian Jenner, Eric Juriatti, Mustafa Turan, Manfred Manßen   +4 more
wiley   +2 more sources

Effect of common maintenance drugs on the risk and severity of COVID-19 in elderly patients

PLoS ONE, 2022
Background Maintenance drugs are used to treat chronic conditions. Several classes of maintenance drugs have attracted attention because of their potential to affect susceptibility to and severity of COVID-19.
Kin Wah Fung, Seo H. Baik, Fitsum Baye, Zhaonian Zheng, Vojtech Huser, Clement J. McDonald   +5 more
doaj   +2 more sources