Results 211 to 220 of about 23,492 (249)

New observations on factor XI deficiency

Haemophilia, 2004
Summary.  Factor (F) XI is an injury‐related bleeding tendency that commonly occurs when trauma involves tissues rich in fibronolytic activators. Severe FXI deficiency is defined when the activity of FXI in plasma is less than 15 U dL−1. The disorder is inherited as an autosomal recessive trait manifesting in homozygotes or compound heterozygotes, and ...
O, Salomon, U, Seligsohn
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Pulmonary Valvulotomy in Factor XI Deficiency

The Thoracic and Cardiovascular Surgeon, 1983
This is the first reported case in the English literature of Factor XI deficiency in a child from India. He underwent open-heart surgery and pulmonary valvulotomy without excessive or delayed hemorrhage using plasma infusion to sustain Factor XI levels at about 40% of normal before, and for 10 days after surgery.
T E, Williams, D, Teske, J, Craenen, A, Miser, J, Miser, H, Saito, R, Baranek   +6 more
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Factor XI Deficiency and Obstetrical Anesthesia

Anesthesia & Analgesia, 2009
Factor XI (FXI) deficiency is a rare inherited coagulation disorder associated with prolonged activated partial thromboplastin time. The severity of bleeding often does not correlate with plasma factor levels. We reviewed the medical and anesthetic records of 13 parturients with FXI deficiency that presented for delivery.
Amarjeet, Singh, Miriam J, Harnett, Jean M, Connors, William R, Camann   +3 more
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Factor XI deficiency in animal models

Journal of Thrombosis and Haemostasis, 2009
The blood coagulation system forms fibrin to limit blood loss from sites of injury, but also contributes to occlusive diseases such as deep vein thrombosis, myocardial infarction, and stroke. In the current model of a coagulation balance, normal hemostasis and thrombosis represent two sides of the same coin; however, data from coagulation factor XI ...
T, Renné, C, Oschatz, S, Seifert, F, Müller, J, Antovic, M, Karlman, P M, Benz   +6 more
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A murine model of factor XI deficiency

Blood Coagulation & Fibrinolysis, 1997
To facilitate investigations into the physiologic and pathologic roles of factor XI, we have developed a murine model of severe factor XI deficiency using the technique of homologous recombination in embryonic stem cells. The factor XI gene was disrupted by introducing a neomycin phosphotransferase gene into the fifth exon.
D, Gailani, N M, Lasky, G J, Broze
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The spectrum of factor XI deficiency in Italy

Haemophilia, 2013
SummaryFactor XI (FXI) deficiency is a rare inherited bleeding disorder invariably caused by mutations in the FXI gene. The disorder is rather frequent in Ashkenazi Jews, in whom around 98% of the abnormal alleles is represented by Glu117X and Phe283Leu mutations.
G. Castaman, S. H. Giacomelli, S. Caccia, F. Riccardi, G. Rossetti, A. Dragani, A. C. Giuffrida, C. Biasoli, S. Duga   +8 more
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The Obstetric Experience of Women With Factor XI Deficiency

Obstetric Anesthesia Digest, 2009
AbstractObjectives. To assess the obstetric outcome in women with factor XI (FXI) deficiency. Design. Retrospective review of medical records. Setting. Tertiary referral university hospital. Population. Women with FXI deficiency. Method. Review of pregnancies over a 10‐year period (1997–2006). Main outcome measures. Pregnancy outcome, mode of delivery,
Claudia, Chi, Ashwini, Kulkarni, Christine A, Lee, Rezan A, Kadir   +3 more
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Factor XI deficiency—resolving the enigma?

Hematology, 2009
Abstract The management of factor XI deficiency is not straightforward for three reasons: firstly, the role of this factor in the coagulation pathway is not clearly understood; secondly, the bleeding tendency, although mild, is unpredictable and does not clearly relate to the factor XI level; and thirdly, all treatment products, although
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Factor XI deficiency and its management

Haemophilia, 2000
Factor XI deficiency has a more variable bleeding tendency than haemophilia A or B. Individuals with severe deficiency have only a mild bleeding tendency, which is typically provoked by surgery, but the risk of bleeding is not restricted to individuals with severe deficiency.
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Molecular Analysis in Factor XI Deficiency

2003
Factor XI (FXI) is the zymogen precursor of an active serine protease that participates in the contact phase of coagulation. Synthesized in the liver, it circulates in the plasma in a noncovalent complex with high molecular weight kininogen (1) at a normal concentration of 5 μg/mL. (For clinical purposes, the normal range is defined as 50-150 U/dL) (2).
Johnson, KM, McVey, JH
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