Results 31 to 40 of about 1,777 (237)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Integrative factorization of bidimensionally linked matrices [PDF]

Biometrics, 2019
AbstractAdvances in molecular “omics” technologies have motivated new methodologies for the integration of multiple sources of high‐content biomedical data. However, most statistical methods for integrating multiple data matrices only consider data shared vertically (one cohort on multiple platforms) or horizontally (different cohorts on a single ...
Jun Young Park, Eric F. Lock
openaire   +3 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

A comment on coposinormal operators

Le Matematiche, 2013
Hyponormal operators are necessarily posinormal, but they need not be coposinormal.  Coposinormality can nevertheless sometimes be an aid in determining hyponormality.
Henry Crawford Rhaly Jr.
doaj  

Purification and correlated measurements of bipartite mixed states

, 2001
We prove that all purifications of a non-factorable state (i.e., the state which cannot be expressed in a form $\rho_{AB}=\rho_A\otimes\rho_B$) are entangled.
A. Uhlmann, A. Uhlmann, B. Englert, B. Englert, C.H. Bennett, C.H. Bennett, J. Bouda, J.S. Bell, Jan Bouda, M. Hillery, M. Zukowski, R.F. Werner, Vladimír Bužek   +12 more
core   +1 more source

Inherited LU-factorizations of matrices

Linear Algebra and its Applications, 2007
Assume that \(A\) is an \(n\times n\) matrix with entries in a ring \(\mathcal{R}\) and that \(a_{11}, a_{22},\dots,a_{nn}\) are invertible elements in \(\mathcal{R}\). Write \(A=B+D+C\) where \(B\) is strictly lower triangular, \(C\) is strictly upper triangular, and \(D\) is diagonal. The authors consider various factorizations containing \(B\), \(D\)
Arav, Marina, Bevis, Jean, Hall, Frank J.   +2 more
openaire   +2 more sources

Factorizations for a class of multivariate polynomial matrices [PDF]

Multidimensional Systems and Signal Processing, 2019
Following the works by Lin et al. (Circuits Syst. Signal Process. 20(6): 601-618, 2001) and Liu et al. (Circuits Syst. Signal Process. 30(3): 553-566, 2011), we investigate how to factorize a class of multivariate polynomial matrices. The main theorem in this paper shows that an $l\times m$ polynomial matrix admits a factorization with respect to a ...
Dong Lu, Dingkang Wang, Fanghui Xiao
openaire   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source