Results 121 to 130 of about 2,411,503 (293)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Fundamentos curriculares para una maestría en producción audiovisual

open access: yesTelos: Revista de Estudios Interdisciplinarios en Ciencias Sociales, 2008
El estudio de los fundamentos curriculares para una maestría en producción audiovisual se apoya en Vílchez (2005), Postner (2001), Maldonado (2001), Boluda (2005), Tünnermann (2005), Miranda (2003), Morles (2005), Vaughan (2000), entre otros.
Maria Alvarado, Nerio Vílchez
doaj  

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

Determinants of attrition in students of the Faculty of Health Sciences University of Cesar Popular among the years 2005 and 2009-I period

open access: yesPraxis, 2014
The present document has an objective to present how the faculty of Health Sciences University Popular del Cesar has been affected by the problem of desertion in the form of undergraduate, in addition, determine the main factors that dominate student ...
Olga Esther Hernández Almanza
doaj  

Reabilitação Cardíaca Após Síndrome Coronária Aguda. Deveremos Continuar a Reabilitar os Doentes de Baixo Risco? Experiência de um Centro [PDF]

open access: yes, 2015
Introdução: A Reabilitação cardíaca (Rc) é um elemento fundamental na prevenção secundária após síndrome coronária aguda (ScA). A American Association of Cardiovascular and Pulmonary Rehabilitation (AAcPR)definiu critérios de estratificação de risco ...
Abreu, A   +14 more
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

LA DINÁMICA DE LOS GASTOS DE CAPITAL EN LAS COMUNIDADES AUTÓNOMAS: UN ANÁLISIS DE SUS DETERMINANTES [PDF]

open access: yes
En el presente trabajo se analizan los factores determinantes de los gastos de capital de las Comunidades Autónomas (CCAA) en el período 1984-1996.
Santiago Lago Peñas
core  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Factores socio económico y incumplimiento terapéutico en pacientes con tuberculosis pulmonar mayores de 15 años - Hospital Regional Hermilio Valdizán Medrano - Huánuco 2013

open access: yesInvestigación Valdizana, 2017
OBJETIVO: Determinar los factores socioeconómicos que se relacionan con el incumplimiento terapéutico de los pacientes con TBC Pulmonar mayor de 15 años del Hospital Regional Hermilio Valdizàn Medrano – Huánuco 2013 MÉTODOS: Se llevó a cabo un estudio
Maura Rios Rojas   +1 more
doaj  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

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