Results 41 to 50 of about 121,507 (253)
Acta Pharmaceutica, 2016 To evaluate the influence of different variables on tablet formulations containing enalapril maleate and indapamide as active substances, two separate experimental designs were employed: one for evaluating powder properties and the other for tablet ...
Szabó Zoltán-István +6 more
doaj +1 more source
Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs–cAMP Signaling
Advanced Science, EarlyView.Our study identifies MINAR1 as a novel regulator of cortical interneuron excitability and seizure susceptibility. MINAR1 is preferentially expressed in SST+ interneurons. Genetic ablation of MINAR1 leads to seizure hypersensitivity, reduced SST+ neuron excitability, and impaired Gαs–cAMP signaling, disrupting the E/I balance.
Wei‐Tang Liu +20 more
wiley +1 more source
Optimization of genistein and daidzein extraction from a tempeh-fermented product of soybean [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2018 Context: Genistein and daidzein, major isoflavone aglycone compounds contained in tempeh, became an interesting subject since their activities as cancer prevention, cardiovascular, and wound healing agents.
Sri H. Yuliani +3 more
doaj
Acta Pharmaceutica, 2018 A reverse-phase HPLC (RP-HPLC) method was developed for strontium ranelate using a full factorial, screening experimental design. The analytical procedure was validated according to international guidelines for linearity, selectivity, sensitivity ...
Kovács Béla +7 more
doaj +1 more source
Advanced Science, EarlyView.A cascade‐responsive MXene@Cu‐MOF/GelMA hydrogel is engineered as a “skeleton–backpack” platform for extensive tracheal repair. The MXene framework scavenges postoperative ROS and converts NIR light into mild hyperthermia, while the Cu‐MOF component provides pH/NIR‐responsive Cu2+ dosing for infection control, angiogenesis, and chondrogenesis.
Liang Guo +8 more
wiley +1 more source
Studying Macromolecular Composition in Cell–Cell Interfaces Using 3D Membrane Reconstitution Systems
Advanced Science, EarlyView.A comprehensive understanding of the interactions between proteins, lipids and glycocalyx components at the immune synapse is still lacking. Here, an artificial and a semi‐artificial model contact system were established to reconstitute the cell‐cell contact in 3D. The model systems enable the examination of macromolecule enrichment or depletion at the
Franziska Ragaller +9 more
wiley +1 more source
Scientia Agropecuaria, 2012 The aim of the present work was to optimize the sensorial and technological features of ice cream. The experimental work was performed in two stages: 1) optimization of lactose enzymatic hydrolysis, and 2) optimization of the process and product.
Cristian Rojas +3 more
doaj +1 more source
Advanced Science, EarlyView.This study outlines the developmental pipeline of a multiplexed nanozyme‐based lateral flow immunoassay for the purpose of ovarian germ cell tumor detection. It demonstrates the application of a design of experiments optimization approach for nanozyme probe conjugate development.
Aida Abdelwahed +10 more
wiley +1 more source
CerâmicaResumo Nos últimos anos a técnica de combustão assistida por micro-ondas vem recebendo uma atenção especial, por ser uma técnica rápida, de baixo custo e de fácil manuseio, que permite obter materiais com boa homogeneidade química.
R. L. B. A. Medeiros +6 more
doaj +1 more source
Optimization of biomass pretreatments using fractional factorial experimental design
Biotechnology for Biofuels, 2018 Background Pretreatments are one of the main bottlenecks for the lignocellulose conversion process and the search for cheaper and effective pretreatment methodologies for each biomass is a complex but fundamental task.
Camila A. Rezende +5 more
doaj +1 more source