Results 61 to 70 of about 500,786 (279)
Vorinostat Potentiates Chemoimmunotherapy in Immune‐Enriched Pancreatic Cancer
Advanced Science, EarlyView.Immune‐enriched pancreatic cancer does not confer a significant survival advantage. SAHA sensitizes these “hot” tumors to chemoimmunotherapy by disrupting a FASN/PARP9‐driven “metabolic trap” and enhancing CD8+ T cell function. A CD8high/FASNhigh/PARP9high signature identifies patients who are most likely to benefit from the “gemcitabine‐nivolumab‐SAHA”
Chen Chen +13 more
wiley +1 more source
CerâmicaResumo Nos últimos anos a técnica de combustão assistida por micro-ondas vem recebendo uma atenção especial, por ser uma técnica rápida, de baixo custo e de fácil manuseio, que permite obter materiais com boa homogeneidade química.
R. L. B. A. Medeiros +6 more
doaj +1 more source
Optimization of biomass pretreatments using fractional factorial experimental design
Biotechnology for Biofuels, 2018 Background Pretreatments are one of the main bottlenecks for the lignocellulose conversion process and the search for cheaper and effective pretreatment methodologies for each biomass is a complex but fundamental task.
Camila A. Rezende +5 more
doaj +1 more source
Factorial designs: an overview with applications to orthodontic clinical trials [PDF]
, 2017 Factorial designs for clinical trials are often encountered in medical, dental, and orthodontic research. Factorial designs assess two or more interventions simultaneously and the main advantage of this design is its efficiency in terms of sample size as
Eliades, Theodore +4 more
core
Studying Macromolecular Composition in Cell–Cell Interfaces Using 3D Membrane Reconstitution Systems
Advanced Science, EarlyView.A comprehensive understanding of the interactions between proteins, lipids and glycocalyx components at the immune synapse is still lacking. Here, an artificial and a semi‐artificial model contact system were established to reconstitute the cell‐cell contact in 3D. The model systems enable the examination of macromolecule enrichment or depletion at the
Franziska Ragaller +9 more
wiley +1 more source
, 1994 The search for fundamental interaction laws continuously stimulates the accelerator community to increase the energy of accelerators. The present need for high-accuracy measurements in already explored energy regions requires a new generation of colliders, the e+ e− factories.
openaire +2 more sources
Markov chain Monte Carlo tests for designed experiments
, 2006 We consider conditional exact tests of factor effects in designed experiments for discrete response variables. Similarly to the analysis of contingency tables, a Markov chain Monte Carlo method can be used for performing exact tests, when large-sample ...
Agresti +21 more
core +2 more sources
Advanced Science, EarlyView.After liver transplantation, ischemia‐reperfusion injury is more severe in pericentral regions. Multiomic analyses of human grafts and mouse models identify FOXO1 activation in pericentral hepatocytes as an upstream driver of SAA secretion. SAA recruits and activates FPR2+ macrophages, amplifying local inflammation. Amilo‐5MER inhibits SAA bioactivity,
Feng Zhang +19 more
wiley +1 more source
Aberration in qualitative multilevel designs
, 2015 Generalized Word Length Pattern (GWLP) is an important and widely-used tool for comparing fractional factorial designs. We consider qualitative factors, and we code their levels using the roots of the unity. We write the GWLP of a fraction ${\mathcal F}$
Chen +22 more
core +1 more source
Advanced Science, EarlyView.This study outlines the developmental pipeline of a multiplexed nanozyme‐based lateral flow immunoassay for the purpose of ovarian germ cell tumor detection. It demonstrates the application of a design of experiments optimization approach for nanozyme probe conjugate development.
Aida Abdelwahed +10 more
wiley +1 more source