Results 41 to 50 of about 127,202 (251)

Sulfation‐Tunable Peptide‐Glycosaminoglycan Hydrogels for Hematopoietic Stem and Progenitor Cell Expansion

open access: yesAdvanced Functional Materials, EarlyView.
Co‐assembly of rationally designed glycosaminoglycan‐binding peptides with sulfated glycosaminoglycans yields supramolecular hydrogels with tunable mechanics and matrix‐mediated cytokine retention. The glycosaminoglycans thereby act as cofactors, driving a coil‐to‐β‐sheet transition that triggers gelation.
Shirel Veretnik   +8 more
wiley   +1 more source

Study of the effect of formulation variables on the characteristics of combination tablets containing enalapril maleate and indapamide as active substances using experimental design

open access: yesActa Pharmaceutica, 2016
To evaluate the influence of different variables on tablet formulations containing enalapril maleate and indapamide as active substances, two separate experimental designs were employed: one for evaluating powder properties and the other for tablet ...
Szabó Zoltán-István   +6 more
doaj   +1 more source

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

open access: yesAdvanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz   +9 more
wiley   +1 more source

Optimization of genistein and daidzein extraction from a tempeh-fermented product of soybean [PDF]

open access: yesJournal of Pharmacy & Pharmacognosy Research, 2018
Context: Genistein and daidzein, major isoflavone aglycone compounds contained in tempeh, became an interesting subject since their activities as cancer prevention, cardiovascular, and wound healing agents.
Sri H. Yuliani   +3 more
doaj  

Reversed phase HPLC for strontium ranelate: Method development and validation applying experimental design

open access: yesActa Pharmaceutica, 2018
A reverse-phase HPLC (RP-HPLC) method was developed for strontium ranelate using a full factorial, screening experimental design. The analytical procedure was validated according to international guidelines for linearity, selectivity, sensitivity ...
Kovács Béla   +7 more
doaj   +1 more source

Experimental design and multicriteria decision making methods for the optimization of ice cream composition

open access: yesScientia Agropecuaria, 2012
The aim of the present work was to optimize the sensorial and technological features of ice cream. The experimental work was performed in two stages: 1) optimization of lactose enzymatic hydrolysis, and 2) optimization of the process and product.
Cristian Rojas   +3 more
doaj   +1 more source

Mechanism‐Driven Nanoformulations for Cognitive Impairment Induced by Intermittent Hypoxia and Periodontitis

open access: yesAdvanced Materials, EarlyView.
Clinically, intermittent hypoxia (IH) is often accompanied by periodontitis, which accelerates cognitive impairment induced by IH. Novel Janus mesoporous gold‐silica nanoformulations (RVG‐Au&mSiO2‐TPP‐VB) enable intranasal delivery, achieve hierarchical targeting to neuronal mitochondria, effectively scavenge reactive oxygen species, inhibit the HIF‐1α/
Kai‐Run Zhang   +15 more
wiley   +1 more source

Optimization of biomass pretreatments using fractional factorial experimental design

open access: yesBiotechnology for Biofuels, 2018
Background Pretreatments are one of the main bottlenecks for the lignocellulose conversion process and the search for cheaper and effective pretreatment methodologies for each biomass is a complex but fundamental task.
Camila A. Rezende   +5 more
doaj   +1 more source

Flax Composites With Improved Interfacial Strength Through Microbially Induced Mineral Precipitation

open access: yesAdvanced Materials, EarlyView.
A bio‐inspired biomineralization strategy introduces an additional hierarchy to flax fiber composites. By controlling microbe‐mediated mineral particle deposition through tuned salt concentrations, stress transfer within the natural fiber composite is enhanced.
Deniz Sayinbas   +5 more
wiley   +1 more source

Cornus Mas L. Seed‐Derived Biosorbent for Methylene Blue Removal: Surface Characterization and Biosorption Performance

open access: yesAdvanced Materials Interfaces, EarlyView.
Cornus mas L. seeds are transformed into a high‐performance biosorbent through chemical modification, effectively removing methylene blue from aqueous solutions. Comprehensive characterization and optimization reveal a maximum biosorption capacity of 71.71 mg g−1, establishing this sustainable, cost‐effective material as a promising solution for ...
Hakan Yıldız   +2 more
wiley   +1 more source

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