Results 191 to 200 of about 2,908,321 (336)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

A Challenging Pulmonary Embolism: When Acute Meets Chronic Thrombus. [PDF]

J Soc Cardiovasc Angiogr Interv
Lee JCY, Singh N, Sakhuja R, Gallen R, Serhal M, Schainfeld R, Rosenfield K.   +6 more
europepmc   +1 more source

Textual Factors: A Scalable, Interpretable, and Data-driven Approach to Analyzing Unstructured Information

, 2018
Lin William Cong, Tengyuan Liang, Xiao Zhang   +2 more
openalex   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The Virtual Feedback Loop: Psychometric Validation of a New Scale to Measure Digital Validation Seeking in Higher Education. [PDF]

Eur J Investig Health Psychol Educ
Nemt-Allah MA, Mostafa MM, Helali MM, Aldawsari HK, Alromaih BS, Ibrahim AR.   +5 more
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Development and Validation of the Needle Stick Injury Prevention Beliefs Scale (NSI-PBS) Based on the Health Belief Model (HBM). [PDF]

Risk Manag Healthc Policy
Khraisat FS, Jarrar M, Issa MR, Al-Bsheish M, Hannan J, Aljabri MM, Rayani AM.   +6 more
europepmc   +1 more source

Unobservable Systematic Risk Factor and Default Prediction

, 2009
Min Qi, Zhang Xiaofei, Xinlei Zhao
openalex   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Factor Retention in Exploratory Multidimensional Item Response Theory. [PDF]

Educ Psychol Meas
Chen C, D'hondt R, Vens C, Van den Noortgate W.   +3 more
europepmc   +1 more source