Results 211 to 220 of about 42,514 (304)

Development and Psychometric Validation of the Geriatric Patient Safety Culture Questionnaire for Intensive Care Nurses. [PDF]

Healthcare (Basel)
Shoukr EMM, Abdallah HMM, Elzeky MEH, Khedr MA, Mohammed AAR, Hassen HAM, Almegewly WH, Baazeem M, Shahine NFM.   +8 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Development and psychometric validation of a culture and tolerance scale in mega sporting events: evidence from an Arab context. [PDF]

Front Psychol
Kenioua M, Krine N, Al Sayed M, Mares G, Alexe CI, Alexe DI.   +5 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Development and Initial Psychometric Validation of the Multidimensional Menopausal Burden Questionnaire (MMBQ-44) in a Sample of Romanian Women. [PDF]

Diagnostics (Basel)
Dragomir AC, Buzatu AR, Marin RC, Moleriu RD, Muntean C, Piroș T, Crintea IN, Alexa AA, Marcu A, Dinuți M.   +9 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

University students' perceptions of social media use and intellectual security: a cross-sectional study in Egypt. [PDF]

Front Sociol
Noufal ZM, Ali EAM, Alazmi M, Al-Taii A, Ashour K.   +4 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

AI literacy for self-regulated learning among pre-service teachers: development and validation of a scale of ethical use, monitoring, motivation, regulation, and evaluation. [PDF]

Front Psychol
Kaya I, Meylani R.
europepmc   +1 more source