Results 221 to 230 of about 41,490 (253)

Measuring daily time experience: development and validation of the Seven-Dimensional Time Quality of Life Scale. [PDF]

Front Psychiatry
Xue B, Liu Y, Jiang X, Ni Z, Sun X, Luo H.   +5 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Validity of a Questionnaire Assessing Preparedness and Self-Reported Confidence of Lebanese Emergency Department Personnel in Managing Ophthalmic Emergencies and Mass Ocular Trauma. [PDF]

Maedica (Bucur)
Daher A, Jabbour N, Abdul Fattah M, Tlaiss Y, Itaoui R, Abiad B.   +5 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Correction to "Neutron Diffraction and Spectroscopic Studies of Intramolecular Tetrel Bonds in Three Fluorinated Zinc Complexes: Significant Redshift in the sp³ C-H Stretch Confirmed by Experiments and Theory". [PDF]

J Am Chem Soc
Lu N, Gurumallappa G, Liu PY, Chan KL, Huang YC, Lin YC, Hsieh YT, Zeng PX, Gowda Y, Tsai MH, Tessema E, Chang HC, Francisco JS.   +12 more
europepmc   +1 more source

Non-consensual sexting among adolescents from ethnocultural minority backgrounds: the role of native peer pressure, self-control, and sexual preoccupation. [PDF]

BMC Psychol
Chasapis D, Touloupis T.
europepmc   +1 more source

Development of a women's health environmental pollution awareness scale and analysis of its psychometric properties. [PDF]

BMC Public Health
Kılavuz M, Ağralı C, Kanbay Y.
europepmc   +1 more source

Psychometric properties of the Patient Health Questionnaire (PHQ-9) in the Dominican Republic. [PDF]

BMC Psychol
García-Batista ZE, Guerra-Peña K, Alvarez-Hernandez A, Cano-Vindel A, Muñoz-Navarro R, Moretti LS, Espinal-Martínez J, Medrano LA.   +7 more
europepmc   +1 more source