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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Social constructivism and its implications for critical media studies [PDF]
While media critics maintain that war coverage has a strong bias toward promoting conflict escalation, their opponents claim that the concept of distorted reality cannot be upheld.
Wilhelm Kempf
doaj
The newfound relationship between extrachromosomal DNAs and excised signal circles
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Las insistencias de lo real. Escenas de reescritura en narrativas de no ficción argentinas
This article explores the question of rewriting as it is presented in nonfiction narratives, based on a series of Argentine texts that include Rodolfo Walsh's Operación masacre (1957), Tomás Eloy Martínez's La pasión según Trelew (1973) and María Moreno ...
Victoria García
doaj +1 more source
Social Facts Explained and Presupposed [PDF]
Attempts are often made to explain collective action in terms of the interaction of individuals. A common objection to such attempts is that they are circular: Since every interaction presupposes the existence of common practices and common practices ...
Hennig, Boris
core +1 more source
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
The Subject, Object and the Duty to Provide Evidence
In our usual language, the word “evidence” represents the mental and logical operation by which we attempt to prove something, to demonstrate, to emphasize a statement that provides credibility to a certain situation.
Cristinel-Ioan Murzea
doaj +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Between Documentary and Provocation. New Tendencies (not only) in Contemporary Polish Holocaust Literature [PDF]
The Holocaust can be seen as a transnational crime, and a collective trauma of universal extension. Therefore national approaches could be seen only as an example out of many others.
Hans-Christian Trepte
doaj

