Results 81 to 90 of about 3,331,363 (306)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Dwie (anty)filozoficzne „gramatyki” Wittgensteina [Two (anti )philosophical grammars of Ludwig Wittgenstein] [PDF]

open access: yesAnaliza i Egzystencja, 2013
Wittgenstein is the author of two conceptions of “grammar”, that were meant to be tools of reaching the same goal: discrediting of the traditional, i.e. “metaphysical” questions of philosophy.
Adam Nowaczyk, Ewa Czesna
doaj  

California Nurses Facts and Figures [PDF]

open access: yes, 2010
Presents data on the demographics, employment, and education of the state's licensed registered nurses; their use of health information technology; job satisfaction; and income; as well as select data on licensed vocational ...

core  

What Normative Facts Should Political Theory Be About? Philosophy of Science meets Political Liberalism [PDF]

open access: yes, 2020
Just as different sciences deal with different facts—say, physics versus biology—so we may ask a similar question about normative theories.
List, Christian, Valentini, Laura
core  

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Soft facts: Thinking practices and the architecture of reality

open access: yesDaimon, 2013
It is common to criticize the idea of objectivity by claiming that we cannot make sense of any cognitive contact with the world that is not constituted by the very materials of our thinking, and to conclude that the idea must be abandoned and that the ...
Hilan Nissor Bensusan   +1 more
doaj   +1 more source

A Non-Reductionist Solution to the Problem of Social Causation [PDF]

open access: yes, 2011
The thesis of the causal closure of the physical world renders mental and social causation philosophically problematic. In The Construction of Social Reality, John Searle offers a partial solution to the problem of the causal efficacy of social and ...
A. dos S. Gouvea, Rodrigo
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Multi-Type FACTS Controllers for Power System Compensation: A Case Study of the Nigerian 48-Bus, 330 kV System

open access: yesNigerian Journal of Technological Development, 2021
Flexible alternating current transmission system (FACTS) devices have provided proficient answers to power system instabilities faced in the systems operations today with very little infrastructural investment fund. This paper investigates the effects of
I. E. Nkan, E. E. Okpo, O. I. Okoro
doaj  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

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