Pregnancy-associated metabolic adaptations in circulating monocytes and macrophages favor clearance functions [PDF]
Frontiers in ImmunologyIntroductionPregnancy requires coordinated immunometabolic adaptations that allow maternal immune tolerance while preserving tissue remodeling and host defense.
Fátima Merech +28 more
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Fetal sex shapes maternal immune adaptation: placental extracellular vesicles differentially reprogram the phenotype, metabolism, and function of circulating monocytes [PDF]
Frontiers in ImmunologyIntroductionMaternal immune adaptation during pregnancy is orchestrated by dynamic signals from the uterine microenvironment, including placental extracellular vesicles (pEVs) released into maternal circulation.
Julieta Avalos +26 more
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A structure and function-based complete mutational map of human hemoglobin using AI [PDF]
Frontiers in ChemistryHemoglobin (Hb), a well-characterized protein central to oxygen transport and molecular medicine, serves as a model for studying how sequence variations influence protein structure and function.
Franco Salvatore +3 more
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Amplitude and frequency encoding result in qualitatively distinct informational landscapes in cell signaling [PDF]
Scientific ReportsCells continuously sense their surroundings to detect modifications and generate responses. Very often changes in extracellular concentrations initiate signaling cascades that eventually result in changes in gene expression. Increasing stimulus strengths
Alan Givré +2 more
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High-Density Iron Nanostructures Grown on Electrospun PVA/Pectin Fibers via Seed-Mediated Strategy for As(V) Remediation. [PDF]
Small MethodsA seed‐assisted anisotropic growth strategy enabling unprecedented iron loading and controlled anisotropic nanostructure formation on electrospun PVA/pectin nanofibers is presented. By decoupling nucleation and growth through sequential Fe2+ then Fe3+ doping, it achieves a 12‐fold increase in accessible iron content, producing rice‐grain‐like ...
Santos AC +5 more
europepmc +2 more sources
Beyond Tanimoto: a learned bioactivity similarity index enhances ligand discovery [PDF]
Frontiers in BioinformaticsStructural similarity metrics such as the Tanimoto coefficient (TC) miss many functionally related compounds—indeed, 60% of similarly bioactive ligand pairs in the ChEMBL database show TC < 0.30, revealing a major blind spot that constrains ligand ...
Gustavo Schottlender +6 more
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Live and let die: signaling AKTivation and UPRegulation dynamics in SARS-CoVs infection and cancer
Cell Death and Disease, 2022 The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen responsible for the coronavirus disease 2019 (COVID-19) pandemic. Of particular interest for this topic are the signaling cascades that regulate cell survival and death, two
Mariana Suaya +6 more
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Author Correction: A new tool to sense pH changes at the neuromuscular junction synaptic cleft
Scientific Reports, 2021 An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Matías Blaustein +7 more
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Journal of Limnology, 2021 In this study we explored how picoplankton community structure and diversity varied along three cascade oligo-mesotrophic reservoirs of the Limay River (Patagonia, Argentina): Alicura, Piedra del Águila and Ramos Mexía.
M. Carolina Bernal +8 more
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Frontiers in Cellular and Infection Microbiology, 2022 Alterations of myeloid cell populations have been reported in patients with tuberculosis (TB). In this work, we studied the relationship between myeloid-derived suppressor cells (MDSC) and monocytes subsets with the immunological responsiveness of TB ...
Nicolás O. Amiano +22 more
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