The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Grading Changes after a Writing Faculty Workshop [PDF]
, 2009 After a workshop on student outcomes for the first-year writing course, the 28 faculty participants discussed the implications of “Development” for critical thinking. This case study of one college’s participatory exercise in improving writing found that
Andrade, Glenna M, Platania, Judith
core +1 more source
Assessing Professionalism: A theoretical framework for defining clinical rotation assessment criteria [PDF]
, 2016 Although widely accepted as an important graduate competence, professionalism is a challenging outcome to define and assess. Clinical rotations provide an excellent opportunity to develop student professionalism through the use of experiential learning ...
Armitage-Chan E +20 more
core +2 more sources
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Curated Collections for Educators: Eight Key Papers about Feedback in Medical Education [PDF]
, 2019 Feedback is an essential part of learning, growth, and academic success. Junior faculty members are often unfamiliar with the grounding literature that defines feedback.
Gottlieb, Michael +5 more
core +1 more source
Characterizing the University of California's tenure-track teaching position from the faculty and administrator perspectives. [PDF]
, 2020 Teaching faculty are a potential mechanism to generate positive change in undergraduate STEM education. One such type of faculty is the Lecturer with Potential Security of Employment (L(P)SOE), a tenure-track faculty line within the University of ...
Harlow, Ashley +3 more
core +1 more source
Building Resilience for Wellness: A Faculty Development Resource
MedEdPORTAL, 2017 Introduction The National Academy of Medicine recently published “A Multifaceted Systems Approach to Addressing Stress Within Health Professions Education and Beyond,” which calls for greater attention to the wellness of health care providers, students ...
Sophia Saeed +4 more
semanticscholar +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
The Talking Points Tool: A Brief Intervention to Support Predoctoral Student and Faculty Advisor Communication [PDF]
, 2019 Excellent relationships between predoctoral students and faculty supervisors can lay the foundation for a satisfying degree program and productive future. Contrarily, poor relationships can frustrate both students and supervisors.
Markey, Mia K. +2 more
core +1 more source