Results 91 to 100 of about 1,478,179 (304)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Faculty Senate meeting, October 26, 1998
, 1998 Agenda: (Informal statements and proposals): A. Distinguished Scholarship Invitational Information / Jenny Chapman -- (President's report) -- (Old business): A. Senate Priorities for 1998-99 -- (New business): A.
Faculty Senate
core
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Faculty Senate meeting, October 26, 2009
, 2009 Agenda: (Informal statements and proposals) -- (President's report) -- (Committee reports): A. Rules / Fritz Hemans -- (New business): A. Foundations of Excellence initiative / Keith PickusAttachments: Reshaping proposal: Office for Faculty Development ...
Faculty Senate
core
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Faculty Senate meeting, February 26, 2018
, 2018 Agenda: (Informal statements and proposals) -- (President's report): KBOR update: Governor’s directive regarding training on Title IX/Internships -- Working on new planning document to follow Foresight 2020 -- KU, KSU, and WSU presented on Career ...
Faculty Senate
core
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Faculty Senate meeting, December 16, 1991
, 1991 Agenda: Consideration of recommendations from the Mission Steering Committee concerning the Board of Regents strategic planAttachments: Notes from meeting of Special Regents Committee, December 9, 1991 / Jay Mandt -- Regents Mission Plan / Jay Mandt -- A
Faculty Senate
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Faculty Senate meeting, September 10, 2018
, 2018 Agenda: (Informal Statement and Proposals) -- (President’s Report) -- (Committee Reports): Rules / Jeff Jarman -- Empty committee seats that need filled -- A. Chair policy review -- B. Faculty workload (reward) committee -- C.
Faculty Senate
core