Results 71 to 80 of about 56,855 (256)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The Faculty of Humanities and Social Sciences of the RPFU and the National Project «Education»

RUDN Journal of Political Science, 2008
The article is devoted to the estimation of particularities of realization on the Faculty of Humanities and Social Sciences of the RPFU of the national project «Education».
E V Kryazheva-Karceva
doaj  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Interview: Elidio La Torre Lagares teaches, Department of Comparative Literature, University of Puerto Rico, Río Piedras

Social Medicine, 2020
Interview between a medical student who was an activist in the protests, with Elidio la Torre Lagares, essayist, narrator, poet and professor of literatura and literary creation at the Faculty of Humanities, University of Puerto Rico.
Iris Mónica Vargas
doaj  

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Political Projecting in the Space of Social Communications: Theory and Technology. Thesis of the Round Table

RUDN Journal of Political Science, 2013
The «round table» on «Political Projecting in the Space of Social Communications: Theory and Technology» was held on April 10, 2013 at the Faculty of History, Political Science and Law of the Russian State University for the Humanities. This «round table»
Mikhail Nikolaevich Grachev, Yuriy Vasil'evich Irkhin, Nikolay Aleksandrovich Borisov, Sergey Ivanovich Boyko, Galina Mikhaylovna Mikhaleva, Roman Alekseevich Agafonov, Oksana Yur'evna Pimenova, Dariya Igorevna Pisarchuk, Dar'ya Borisovna Kazarinova, Andrey Alekseevich Kinyakin   +9 more
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

RUSSIAN NATIONAL ACADEMIC CONFERENCE FOR YOUNG SCIENTIST “LINGUISTIC WORLDVIEW PROBLEMS IN SYNCHRONY AND DIACHRONY”

Вестник Мининского университета, 2017
Russian national academic conference for young scientist “Linguistic worldview problems in synchrony and diachrony” was held on April 15-16, 2014 on the basis of Russian Language and Culture of Speech department on the faculty of humanities in Minin ...
N. E. Petrova, E. N. Shirokova
doaj   +2 more sources