Results 31 to 40 of about 6,307 (191)

Gastrointestinal risk profile of tigecycline, omadacycline and eravacycline: Evidence from the FDA adverse event reporting system

Acta Pharmaceutica
This study assessed the gastrointestinal (GI) safety profiles of tigecycline, omadacycline, and eravacycline through a retrospective disproportionality analysis of reports submitted to the FDA Adverse Event Reporting System (FAERS) between the second ...
Wang Zhu, Gan Guoping, Yao Haiping
doaj   +1 more source

Bisphosphonate-related ocular adverse events: a pharmacovigilance study based on the FAERS database

Endocrine Connections
This retrospective study aimed to identify and characterize signals of ocular adverse events (AEs) related to bisphosphonates (BPs) using FDA adverse event reporting system (FAERS) data (Q1 2004 to Q3 2024) to inform future safety investigations ...
Yue Cui, Zhihui Song, Xinglong Wang
doaj   +1 more source

Evaluating the Evolving Real‐World Adverse Events of GLP‐1RAs Using FDA Adverse Event Reporting System (FAERS)

Obesity, EarlyView.
Web portal for interrogating Adverse Events of GLP‐1 RA in diabetes vs weight control/obesity. ABSTRACT Objective This study aimed to assess the spectrum and frequency of adverse events (AEs) linked to glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) using the US FDA Adverse Event Reporting System (FAERS).
David Stone, Mary Playdon, Stephen D. Hursting, Aik Choon Tan   +3 more
wiley   +1 more source

Association of GnRH agonists with depression and suicide/self-injury: a FAERS pharmacovigilance study

Endocrine Connections
Background: The relationship between gonadotropin-releasing hormone agonists (GnRH-as) and depression and suicide/self-injury (DASSI) remains controversial.
Jinhua Liu, Liping Xue, Ruolin Chen, Ying Liu, Fanxiang Zeng, Peiguang Niu, Jintuo Zhou, Yanting Zhu, Jinhua Zhang, Huajiao Chen   +9 more
doaj   +1 more source

Immune checkpoint inhibitor‐induced arrhythmias: Mechanistic insights from clinical and preclinical studies

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy, but their efficacy continues to be limited by immune‐related adverse events. Among these, ICI‐induced cardiac arrhythmias are increasingly recognised as a major adverse reaction, encompassing a broad spectrum of clinical phenotypes, including conduction blocks, atrial fibrillation and
Anand R. Ramalingam, Zoltán Márton Köhler, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source

Spontaneous reports of adverse reactions to methotrexate: retrospective analysis in the Russian Federation

Фармакоэкономика
Background. Methotrexate (MTX) is a widely prescribed medication known for its pronounced anti-inflammatory and anti-tumor effects. However, its use is associated with risks of adverse drug reactions (ADRs) including gastrointestinal tract, infectious ...
S. A. Stefanova, Ya. D. Belousova, V. V. Rafalskiy   +2 more
doaj   +1 more source

Comparison of pneumonitis risk between immunotherapy alone and in combination with chemotherapy: an observational, retrospective pharmacovigilance study

Frontiers in Pharmacology, 2023
Importance: Checkpoint inhibitor pneumonitis (CIP) is a rare but serious adverse event that may impact treatment decisions. However, there is limited information comparing CIP risks between immune checkpoint inhibitor (ICI) monotherapy and combination ...
Huixia Li, Yifan Zheng, Peihang Xu, Zimu Li, Yukun Kuang, Xiaoqing Feng, Junhao He, Jia Li, Xiao Chen, Lihong Bai, Ke-Jing Tang, Ke-Jing Tang   +11 more
doaj   +1 more source

Intraoperative Cardiac Events During Pediatric Cardiac Magnetic Resonance Imaging Under Anesthesia: A Retrospective Cohort Study

Pediatric Anesthesia, Volume 36, Issue 9, Page 1143-1152, September 2026.
ABSTRACT Background Children with congenital heart disease (CHD) frequently undergo cardiac magnetic resonance imaging (MRI) under anesthesia. Although these procedures lack surgical stimulus, patients remain physiologically vulnerable, and the incidence of perioperative cardiovascular instability in this setting is poorly defined.
Theodora Wingert, Justine Liang, Kelly Feldman, Amelie Delaporte, Christine Nguyen‐Buckley, Tristan Grogan, Alexandre Joosten, John Paul Finn, Ihab Ayad   +8 more
wiley   +1 more source

Sexual Safety Signals of Common Antidiabetic Drugs: Insights From FAERS Disproportionality Analysis

Andrology, Volume 14, Issue 6, Page 1627-1635, September 2026.
ABSTRACT Background Erectile dysfunction is a prevalent and distressing complication of diabetes mellitus that markedly affects quality of life in male patients. Although the role of diabetes in erectile dysfunction is well‐established, potential drug‐induced sexual dysfunction associated with commonly prescribed antidiabetic medications remains ...
Shan Lin, Xuefeng Ding, Xin Dang, Qingyuan Zhan   +3 more
wiley   +1 more source

Relationship between thromboembolic events and thrombopoietin receptor agonists: a pharmacovigilance analysis of the FDA Adverse Event Reporting System and the Japanese Adverse Drug Event Report

BMJ Open
Objective Thrombopoietin receptor agonists (TPO-RAs) are widely used in thrombocytopenia, yet their association with thromboembolic events (TEEs) remains concerning.
Zheng Wang, Xiaojia Huang, Yanqin Huang, Xinhang Liao, Changze Zhang, Liangping Yu   +5 more
doaj   +1 more source