Results 51 to 60 of about 9,302 (232)

Bisphosphonate-related ocular adverse events: a pharmacovigilance study based on the FAERS database

Endocrine Connections
This retrospective study aimed to identify and characterize signals of ocular adverse events (AEs) related to bisphosphonates (BPs) using FDA adverse event reporting system (FAERS) data (Q1 2004 to Q3 2024) to inform future safety investigations ...
Yue Cui, Zhihui Song, Xinglong Wang
doaj   +1 more source

Immune checkpoint inhibitor‐induced arrhythmias: Mechanistic insights from clinical and preclinical studies

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy, but their efficacy continues to be limited by immune‐related adverse events. Among these, ICI‐induced cardiac arrhythmias are increasingly recognised as a major adverse reaction, encompassing a broad spectrum of clinical phenotypes, including conduction blocks, atrial fibrillation and
Anand R. Ramalingam, Zoltán Márton Köhler, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source

Association of GnRH agonists with depression and suicide/self-injury: a FAERS pharmacovigilance study

Endocrine Connections
Background: The relationship between gonadotropin-releasing hormone agonists (GnRH-as) and depression and suicide/self-injury (DASSI) remains controversial.
Jinhua Liu, Liping Xue, Ruolin Chen, Ying Liu, Fanxiang Zeng, Peiguang Niu, Jintuo Zhou, Yanting Zhu, Jinhua Zhang, Huajiao Chen   +9 more
doaj   +1 more source

rhGH-FAERS-Research Data

本研究所使用的数据来源于 美国FDA不良事件报告系统（FAERS） 的公开季度数据文件（时间范围：XXXX年X月至XXXX年X月），所有原始数据均可在FDA官方网站（https://www.fda.gov/drugs/questions-and-answers-fdas-adverse-event-reporting-system-faers/fda-adverse-event-reporting-system-faers-public-dashboard）免费获取。FAERS数据为自发报告系统 ...
Hong, Qingxia
core   +1 more source

Harnessing Machine Learning to Improve Healthcare Monitoring with FAERS [PDF]

, 2022
This research study investigates the potential of machine learning techniques to improve healthcare monitoring through the utilization of data from the FDA Adverse Event Reporting System (FAERS).
Kamaraj, Santhosh, Jing, Zhang
core  

Cyclin‐dependent kinase 4/6 (CDK4/6) inhibitor‐induced hepatotoxicity and its resolution: a study of seven cases

Histopathology, EarlyView.
CDK4/6 inhibitor‐induced liver injury represents a clinically significant and histologically distinctive form of drug‐induced hepatotoxicity, most commonly encountered with ribociclib. The predominant pattern is severe acute hepatocellular injury, frequently accompanied by lymphocytic cholangitis, a combination that, in the appropriate clinical context,
Sunayana Misra, Lisa Centeno, Dupinder Singh, Romil Saxena, Rifat Mannan   +4 more
wiley   +1 more source

Relationship between thromboembolic events and thrombopoietin receptor agonists: a pharmacovigilance analysis of the FDA Adverse Event Reporting System and the Japanese Adverse Drug Event Report

BMJ Open
Objective Thrombopoietin receptor agonists (TPO-RAs) are widely used in thrombocytopenia, yet their association with thromboembolic events (TEEs) remains concerning.
Zheng Wang, Xiaojia Huang, Yanqin Huang, Xinhang Liao, Changze Zhang, Liangping Yu   +5 more
doaj   +1 more source

A real-world pharmacovigilance study of FDA Adverse Event Reporting System (FAERS) events for osimertinib

Scientific Reports, 2022
Osimertinib was a third-generation, irreversible epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), which approved by the US Food and Drug Administration (FDA) in 2015 for treatment of non-small cell lung cancer (NSCLC). Our study was
Yanchao Yin, Yamin Shu, Junru Zhu, Feie Li, Juan Li   +4 more
doaj   +1 more source

Comparative Adverse Event Reporting Patterns of Amoxicillin and Amoxicillin/Clavulanic Acid in FAERS: A 2022–2025 Disproportionality Analysis [PDF]

Health Sci Rep
ABSTRACT Background and Aims Amoxicillin, alone or combined with clavulanic acid, is widely used for the treatment of bacterial infections. While clavulanic acid expands amoxicillin's antibacterial spectrum by inhibiting β‐lactamases, differences in their real‐world safety profiles and reporting patterns remain relevant for pharmacovigilance and ...
Irrera P, Ammendolia I, Frattima G, Luca F, Campolo M, Esposito E, Ardizzone A, Calapai F.   +7 more
europepmc   +2 more sources

Artificial Intelligence‐Driven Precision Bisphosphonate Therapy in Osteoporosis: Mechanisms, Clinical Applications, Risks, and Future Directions

Orthopaedic Surgery, EarlyView.
This comprehensive review integrates 17 benchmark studies to illustrate the transition of osteoporosis management toward precision medicine. The schematic highlights three key clinical applications: AI‐driven opportunistic screening from routine CTs, precision pharmacotherapy selection, and the predictive prevention of adverse events like MRONJ ...
Xiang Yao, Yicong Chao, Xiao Gu, Jingtao Peng, Jishan Yuan, Wei Shi, Fuguo Zhang, Qiwen Bao   +7 more
wiley   +1 more source