Results 51 to 60 of about 9,966 (258)

Network medicine and systems pharmacology approaches to predicting adverse drug effects

British Journal of Pharmacology, EarlyView.
Identifying and understanding the relationships between drug intake and adverse effects that can occur due to inadvertent molecular interactions between drugs and targets is a difficult task, especially considering the numerous variables that can influence the onset of such events.
Alessio Funari, Giulia Fiscon, Paola Paci   +2 more
wiley   +1 more source

Drug-induced dementia: a pharmacovigilance analysis of the FAERS database

Expert Opinion on Drug Safety
Dementia is a global public health challenge. Certain medications, such as anticholinergics and benzodiazepines, have been linked to an increased dementia risk. However, most studies focused on a limited range of drugs, lacking a comprehensive overview.
Yu Wang, Jiahe Kong, Yi Yang, Yifan Zheng, Jia Li   +4 more
openaire   +2 more sources

Drug Safety During Breastfeeding: A Comparative Analysis of FDA Adverse Event Reports and LactMed^®

Pharmaceuticals
Background/Objectives: While breastfeeding is highly recommended, breastfed infants may be exposed to drugs by milk due to maternal pharmacotherapy, resulting in a risk of adverse drug events (ADE) or reactions (ADRs). The U.S.
Hülya Tezel Yalçın, Nadir Yalçın, Michael Ceulemans, Karel Allegaert   +3 more
doaj   +1 more source

Downregulation of Organic Anion Transporting Polypeptide (OATP) 1B1 Transport Function by Lysosomotropic Drug Chloroquine: Implication in OATP-Mediated Drug-Drug Interactions [PDF]

, 2016
Organic anion transporting polypeptide (OATP) 1B1 mediates the hepatic uptake of many drugs including lipid-lowering statins. Decreased OATP1B1 transport activity is often associated with increased systemic exposure of statins and statin-induced myopathy.
Abuznait, Alaa H., Alam, Khondoker, Ding, Kai, Li, Lang, Pahwa, Sonia, Wang, Xueying, Yue, Wei, Zhang, Pengyue   +7 more
core   +2 more sources

From Trials to Practice: A 2025 Review of Idecabtagene Vicleucel and Ciltacabtagene Autoleucel Efficacy Across Clinical Studies and Real‐World Evidence

European Journal of Haematology, EarlyView.
ABSTRACT B‐cell maturation antigen (BCMA)‐directed chimeric antigen receptor (CAR) T‐cell therapies have revolutionized the approach and management of relapsed/refractory multiple myeloma (RRMM), and as of 2025, idecabtagene vicleucel (ide‐cel) and ciltacabtagene autoleucel (cilta‐cel) are the only BCMA‐targeted CAR T‐cell therapies approved by the FDA.
Hector Garcia Pleitez, Sakditad Saowapa, Andrea Ortiz Maldonado, Chanakarn Kanitthamniyom, Diego Olavarria Bernal, Lukman Tijani   +5 more
wiley   +1 more source

RxNorm for drug name normalization: a case study of prescription opioids in the FDA adverse events reporting system

Frontiers in Bioinformatics
Numerous studies have been conducted on the US Food and Drug Administration (FDA) Adverse Events Reporting System (FAERS) database to assess post-marketing reporting rates for drug safety review and risk assessment. However, the drug names in the adverse
Huyen Le, Ru Chen, Stephen Harris, Hong Fang, Beverly Lyn-Cook, Huixiao Hong, Weigong Ge, Paul Rogers, Weida Tong, Wen Zou   +9 more
doaj   +1 more source

Association between proton pump inhibitors and rhabdomyolysis risk: a post-marketing surveillance using FDA adverse event reporting system (FAERS) database

Therapeutic Advances in Drug Safety, 2023
Background: This research aims to explore and compare the signals of rhabdomyolysis from the use of Proton pump inhibitors (PPIs) using the United States Food and Drug Administration Adverse Event Reporting System (FAERS) database.
Ali F. Altebainawi, Lulwa A. Alfaraj, Amjad A. Alharbi, Fadwa F. Alkhuraisi, Thamir M. Alshammari   +4 more
doaj   +1 more source

Detecting associations between behavioral addictions and dopamine agonists in the Food & Drug Administration's Adverse Event database [PDF]

, 2014
Background/Aims Studies have reported higher prevalences of four behavioral addictions (binge eating, compulsive shopping, hypersexuality, and pathological gambling) in dopamine agonist-treated Parkinson's disease relative to non-dopamine agonist ...
Gendreau, Katherine E., Potenza, Marc N.
core   +2 more sources

Is the Safety of Finasteride Correlated With Its Route of Administration: Topical Versus Oral? A Pharmacovigilance Study With Data From the United States Food and Drug Administration Adverse Event Reporting System

International Journal of Dermatology, EarlyView.
ABSTRACT Background The United States Food and Drug Administration (FDA) approved oral finasteride for androgenetic alopecia. In 2022, approximately 2.6 million U.S. men used it for hair loss and prostate conditions. Post‐finasteride syndrome (PFS), proposed in 2012, involves persistent sexual and neuropsychiatric adverse events (AEs) after cessation ...
Aditya K. Gupta, Mesbah Talukder, Sharon A. Keene, Mary A. Bamimore   +3 more
wiley   +1 more source

Effects of vertical confinement on gelation and sedimentation of colloids [PDF]

, 2017
We consider the sedimentation of a colloidal gel under confinement in the direction of gravity. The confinement allows us to compare directly experiments and computer simulations, for the same system size in the vertical direction.
Fullerton, Christopher J., Hallett, James, Jack, Robert L., Razali, Azaima, Royall, C. Patrick, Turci, Francesco   +5 more
core   +3 more sources