Results 101 to 110 of about 1,661,739 (261)

Outcome of mechanical mode of induction in failed primary labor induction.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2009
To determine the role of an alternate (mechanical) inducing agent in failed labor induction.Quasi-experimental study.Labor Ward at Mother and Child Health Center (MCH), Pakistan Institute of Medical Sciences (PIMS) from May 1999 to July 2003.Women with singleton term gestation and normal live fetus undergoing indicated induction of labor were included ...
Syeda Batool, Mazhar, Kausar, Jabeen
openaire   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Standard definitions of chromatic induction fail to describe induction with S-cone patterned backgrounds

Vision Research, 2008
Inducing patterns that selectively stimulate the S cones can induce large shifts in color appearance. For example, a "peach" test-ring presented within contiguous purple and non-contiguous lime inducing rings appears pink while the physically identical peach test-ring appears orange when presented within contiguous lime and non-contiguous purple ...
openaire   +2 more sources

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Cannabinoids facilitate LTD induction in the VTA.

, 2013
(A) HFS failed to induce LTP in naïve rat VTA. (B) LFS failed to induce LTD in naïve rat VTA. (C) HFS failed to induce LTP from the VTA of HU210-treated rats. (D) LFS induced LTD from the VTA of chronic HU210-treated rats.
Zul Merali (126741), Robert Monette (358667), Guang Bai (358665), Wandong Zhang (133483), Zhengping Jia (267394), Jing Han (43038), Zhou Zhu (46647), Xia Zhang (41398), Zhiqiang Liu (182265), Qiaohua Zheng (358666), Lin Xu (94491), Lintao Jia (358663), Wei Ren (267391), Wei Wang (17594), Jean-Christian Maillet (358664)   +14 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

One-layer transformers fail to solve the induction heads task

CoRR
A simple communication complexity argument proves that no one-layer transformer can solve the induction heads task unless its size is exponentially larger than the size sufficient for a two-layer transformer.
Clayton Sanford, Daniel Hsu 0001, Matus Telgarsky   +2 more
openaire   +3 more sources