Results 161 to 170 of about 11,498,837 (391)

Network failure: Biotechnology firms, clusters and collaborations far from the world superclusters

, 2020
Michael Gilding, Julia Brennecke, Vikki Bunton, Dean Lusher, Peter L. Molloy, Alex Codoreanu   +5 more
openalex   +2 more sources

Structure-Sensitive Mechanism of Nanographene Failure

, 2010
The response of a nanographene sheet to external stresses is considered in terms of a mechanochemical reaction. The quantum chemical realization of the approach is based on a coordinate-of-reaction concept for the purpose of introducing a mechanochemical
A. Chuvilin, A. Hemmasizadeh, A. Sakhaee-Pour, A. Tobolski, C. Jin, C. Lee, C. Li, E. A. Nikitina, E. A. Nikitina, E. F. Sheka, E. F. Sheka, E. F. Sheka, E. F. Sheka, F. Liu, G. Lier Van, H. Bu, J.-L. Tsai, K. Hashemnia, K. Kudin, L. H. Shaymardanova, M. J. S. Dewar, M. M. Shokrieh, M. Topsakal, N. A. Popova, P. Pulay, V. A. Popova, V. A. Zayets, V. D. Khavryutchenko, V. Khavryutchenko, X. Wei, Y. Gao, Y. Guo   +31 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

Revista Española de Cardiología, 2016
P. Ponikowski, A. Voors, S. Anker, Héctor Bueno, John G. F. Cleland, Andrew J.S. Coats, Volkmar Falk, J. González-Juanatey, V. Harjola, E. Jankowska, Mariell Jessup, Cecilia Linde, P. Nihoyannopoulos, John Parissis, B. Pieske, Jillian P Riley, Giuseppe M. C. Rosano, L. Ruilope, F. Ruschitzka, Frans H. Rutten, Peter van der Meer   +20 more
semanticscholar   +1 more source

Fatigue failure load indicator [PDF]

, 1979
An indicator for recording the load at which a fatigue specimen breaks during the last cycle of a fatigue test is described. A load cell is attached to the specimen which is alternately subjected to tension and compression loads.
Davis, D. C., Davis, W. T., Imig, L. A.
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Slip‐stick peel failure of a semicrystalline adhesive [PDF]

, 1975
James L. Racich, James A. Koutsky
openalex   +1 more source