Results 161 to 170 of about 8,833,991 (337)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Lumbar Spine Surgery. Indications, Techniques, Failures and Alternatives [PDF]

, 1984
R. S. Maurice‐Williams
openalex   +1 more source

Byzantine Failure against Colluding Attacks in Cloud Data [PDF]

, 2022
Noman Mazher, Shafiq Hussain
openalex   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

ULTIMATE STRENGTH, DUCTILITY, AND FAILURE MODE OF HIGH-STRENGTH FRICTIONAL BOLTED JOINTS MADE OF HIGH-STRENGTH STEEL [PDF]

, 2023
Zice Qin, Hideki Moriyama, Takashi Yamaguchi, Mitsuhiro Shigeishi, Yu-Yue Xing, Akira Hashimoto, P Moe, D Beg, J Lopatic, P Moe, D Beg, Y Wang, Y Lyu, G Li, J Liew, K Homma, M Tanaka, K Matsuoka, T Kasuya, H Kawasaki, C Miki, A Ichikawa, T Kusunoki, F Kawabata, D Duc, Y Okui, K Hagiwara, M Nagai, M Rahman, Y Okui, T Shoji, M Komuro, P Moe, D Beg, P Moe, Y Toda, T Yamaguchi, Y Mineyama, Naoe   +38 more
openalex   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Blood Urea Nitrogen as an Integrated Biomarker for Hospitalized Heart Failure

, 2012
Naoki Sato
openalex   +2 more sources

Review of: "American Mission in Afghanistan: Geopolitical Interests, Strategies and Reasons of Failure" [PDF]

, 2023
Faiza Bashir
openalex   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Erratum for Alveolar Type II Cells Escape Stress Failure Caused By Tonic Stretch Through Transient Focal Adhesion Disassembly [PDF]

, 2020
Xiaoyang Liu, Xiaofei Chen, Yanhong Ren, Qingyuan Zhan, Chen Wang, Chun Yang   +5 more
openalex   +1 more source