Results 171 to 180 of about 2,757,263 (268)

Periosteum-enhanced triple-pass Krackow stitch provides higher ultimate load than conventional Krackow methods in a bovine patellar tendon model: a controlled biomechanical study. [PDF]

BMC Musculoskelet Disord
Kahraman HÇ, Demirel M, Yıldırım C, Karaköse R, Gücük S, Bozdağ SE, Kocabey Y.   +6 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Integrated comprehensive assessment for predicting weaning success in difficult-to-wean critically ill patients: the WEAN-US study. [PDF]

Crit Care
Fogagnolo A, Dres M, Murgolo F, Grasso S, Brazzoli B, Pasa G, Khan MR, Azzolina D, Alvisi V, Scaramuzzo G, Volta CA, Spadaro S.   +11 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Herpes Simplex Virus Hepatitis: An Overlooked Cause of Acute Liver Failure Across a Broad Spectrum of Immunocompromise. [PDF]

Liver Int
Mondelli MU, Ludovisi S, Di Matteo A, Şahin GÖ, Irving W, European Society of Clinical Microbiology and Infectious Diseases Study Group for Viral Hepatitis (ESGVH).   +5 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Linking Myocardium Hypercontractility to Microvasculature Dysfunction and Inflammation through NLRP3 Inflammasome Activation

Journal of Molecular and Cellular Cardiology Plus
Vasco Sequeira, Katharina Ermer, Jan M. Federspiel, Mark Waddingham, Jan Dudek, Hirotsugu Tsuchimochi, Christoph Maack, James Pearson   +7 more
doaj   +1 more source

Experiences Related to Learned Helplessness and Support Needs Among Patients with Recurrent Implantation Failure Undergoing in vitro Fertilization and Embryo Transfer: A Qualitative Study. [PDF]

Psychol Res Behav Manag
Guo S, Peng X, Xie C, Leng W, Zhou L, Zhang M, Cai S.   +6 more
europepmc   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source