Results 161 to 170 of about 2,766,558 (268)

The NAVIGATE trial: early identification and management of mild acute hypoxemic failure, does timing matter outside ICUs? [PDF]

J Thorac Dis
Frat JP, Coudroy R, Thille AW.
europepmc   +1 more source

Unraveling the Impact of COVID-19 Lockdowns on Youth Sports and Physical Activity: Insights From a Retrospective Cohort Study in Italy

International Journal of Pediatrics
E. Lodi, P. A. Gasparini, A. Brusini, M. L. Poli, G. Savino, M. G. Modena   +5 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Incremental effects of vericiguat added to sacubitril/valsartan in heart failure with nonpreserved ejection fraction: a real-world study. [PDF]

Int J Cardiol Heart Vasc
Kinoshita H, Kimura K, Masada K, Shimonaga T, Sugino H.   +4 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Displacement of synthetic cranioplasty implant due to mechanical failure of titanium fixation plating: illustrative case. [PDF]

J Neurosurg Case Lessons
Branscom GA, Ren EM, Lemonick MB, Ezzat B, Rifi Z, Majidi S, Kellner CP, Shigematsu T.   +7 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Periosteum-enhanced triple-pass Krackow stitch provides higher ultimate load than conventional Krackow methods in a bovine patellar tendon model: a controlled biomechanical study. [PDF]

BMC Musculoskelet Disord
Kahraman HÇ, Demirel M, Yıldırım C, Karaköse R, Gücük S, Bozdağ SE, Kocabey Y.   +6 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Integrated comprehensive assessment for predicting weaning success in difficult-to-wean critically ill patients: the WEAN-US study. [PDF]

Crit Care
Fogagnolo A, Dres M, Murgolo F, Grasso S, Brazzoli B, Pasa G, Khan MR, Azzolina D, Alvisi V, Scaramuzzo G, Volta CA, Spadaro S.   +11 more
europepmc   +1 more source