Results 131 to 140 of about 30,256,552 (351)
Failure analysis of a set of stainless steel disc springs
, 2006 This paper analyses the failure of a set of disc springs, broken in service in a seawater environment and at high temperature. These components were manufactured using a 17-7 PH, UNS S17700 precipitation hardening stainless steel.
Atxaga, G., Irisarri, A. M., Pelayo, A.
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Study of the failure of a duplex stainless steel valve
, 2009 A study has been performed to determine the reason for the failure of a group of duplex stainless steel valves after 15 years in service. Chemical analysis did not agree with the required quality.
Atxaga, G., Irisarri, A. M.
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3D Failure Analysis of Pure Mechanical and Pure Chemical Degradation in Fuel Cell Membranes
, 2017 Lifetime-limiting failure of fuel cell membranes is generally attributed to their chemical and/or mechanical degradation. Although both of these degradation modes occur concurrently during operational duty cycles, their uncoupled investigations can ...
Y. Singh, F. Orfino, M. Dutta, E. Kjeang
semanticscholar +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Study of the failure of one machining tool
, 2010 This paper presents the study of the failure of one tool that was broken in two pieces inducing a serious damage in the component that was being machined. The main difficulty for this analysis came up against the need of keeping the broken tool in the as-
Irisarri, A. M., Silveira, E.
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Failure analysis of the end of a shaft of an engine
, 2010 The aim of this paper is to analyse the root causes of the premature failure of the end of the shaft of an engine, which was theoretically manufactured using a C45 steel.
Atxaga, G., Irisarri, A. M.
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E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Study on the root causes for the premature failure of an aircraft turbine blade
, 2009 A study on the root causes of the premature failure of a set of blades belonging to the high pressure turbine of an aircraft engine has been carried out. These blades were manufactured using a precipitation hardened nickel base alloy. The study consisted
Atxaga, G. +3 more
core +1 more source