Results 121 to 130 of about 30,256,552 (351)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Failure intensity of offshore power plants under varying maintenance policies [PDF]

, 2019
System reliability of an offshore power plant with several gas turbine engines is analyzed in this study to understand the failure intensity of a selected gas turbine engines under varying maintenance activities.
Perera, Lokukaluge Prasad, Manguinho, Diego A.P., Valland, Anders, Machado, Mario M.   +3 more
core   +1 more source

Functional Failure Criticality Assessment and Control of Power Distribution Systems: Failure Prioritization Using AHP

IEEE Access
Power distribution systems consist of critical infrastructure with various categories of assets that require rigorous maintenance programs to ensure their reliability and performance for all stakeholders.
Attanayake Mudiyanselage Sakura Rancy Harshani Attanayake, R. M. Chandima Ratnayake, Tore Markeset   +2 more
doaj   +1 more source

Approaches to Methods of Risk Analysis and Assessment Regarding the Gas Supply to a City

Energies, 2018
Analysis and assessment of the reliability and safety of a gas-supply system is a key issue, given its status as critical infrastructure. A gas-supply system is characterised by continuous operation and a consequent need to achieve a high level of ...
Barbara Tchórzewska-Cieślak, Katarzyna Pietrucha-Urbanik   +1 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Verification of failure mechanisms and design philosophy for a bolt-anchored and fibre-reinforced shotcrete lining

, 2020
Falling or sliding of loose blocks is one of the most common failure modes in a rock tunnel. For tunnels in hard and jointed rock, fibre-reinforced shotcrete (sprayed concrete) in combination with rock bolts is one of the most commonly used supports to ...
Sjölander, Andreas, Ansell, Anders, Sjölander, Andreas,, Ansell, Anders,, Hellgren, Rikard, Malm, Richard,, Malm, Richard, Hellgren, Rikard,   +7 more
core   +1 more source

Induction Motor Failure Analysis: An Automatic Methodology Based on Infrared Imaging

IEEE Access, 2018
The main techniques used for failure analysis in induction motors are limited because they are not capable of detecting all the faults present in an induction motor.
E. Resendiz-Ochoa, R. Osornio-Ríos, J. P. Benitez-Rangel, Rene de J. Romero-Troncoso, L. A. Morales-Hernández   +4 more
semanticscholar   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source