Results 51 to 60 of about 2,145,027 (259)

On Hierarchical Composite Endpoints in Pediatric Cancer Supportive Care: Illustrative Examples From Two Multi‐Center Phase‐III Randomized Clinical Trials

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric supportive care clinical trials often involve multiple clinically important outcomes, complicating trial interpretation. Hierarchical composite endpoints (HCEs) provide a framework to integrate key outcomes according to clinical importance.
Willem H. Collier   +11 more
wiley   +1 more source

The role of bridging nodes in behavioral network models of complex engineered systems

open access: yesDesign Science, 2018
Recent advances in early stage failure analysis approaches have introduced behavioral network analysis (BNA), which applies a network-based model of a complex engineered system to detect the system-level effect of ‘local’ failures of design variables and
Hannah S. Walsh   +2 more
doaj   +1 more source

A Population‐Based Study on Childhood Aplastic Anemia—Incidence, Outcomes, and Health‐Related Quality of Life

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Childhood aplastic anemia (AA) is a rare disease, and both the disease itself and its treatment cause significant morbidity. We aimed to determine the contemporary incidence of childhood AA in Finland, to compare the clinical characteristics of AA against inherited bone marrow failure syndromes (IBMFS) and refractory cytopenia of ...
Lauri‐Matti Kulmala   +8 more
wiley   +1 more source

Optimizing Retention Bunkers in Copper Mines with Numerical Methods and Gradient Descent

open access: yesApplied Sciences
This study examines the optimization of ore receiving bins in underground copper mines, targeting the reduction of rapid wear and tear on bin components.
Piotr Bortnowski   +4 more
doaj   +1 more source

Hardware-in-the-loop performance analysis of a railway traction system under sensor faults

open access: yesThe Journal of Engineering, 2019
Fault mode and effects analysis (FMEA) has been used during decades for analysing the effects of faults in different applications. Initially, FMEA based on risk priority numbers provided information about the effects in the system, but during the last ...
Fernando Garramiola   +4 more
doaj   +1 more source

A New Function-Topology-Based Method for Assessing Passive Safety of Mechatronics Systems

open access: yesIEEE Access, 2020
Various safety assessment models for predicting the future state of systems based on online monitoring data have been proposed. However, the complexity and interdependencies of mechatronics systems make it improbable to predict and prevent all possible ...
Shuai Lin   +3 more
doaj   +1 more source

The Role of Chemotherapy in Pediatric Myoepithelial Carcinoma: A Systematic Review of the Literature

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Myoepithelial carcinoma (MEC) in pediatric patients is a rare and aggressive malignancy characterized by heterogeneous morphology and variable molecular features. The optimal role of chemotherapy remains unclear. We conducted a systematic review according to PRISMA 2020 guidelines to evaluate chemotherapy in pediatric and young‐adult patients ...
Marco Salvi   +7 more
wiley   +1 more source

Approximate Bayesian Computation for a Dual-Failure-Modes Models and Its Application to Failure Times Data

open access: yesIEEE Access
In this study, comprehensive approximate Bayesian computation (ABC) technique is explored, and develop for an innovative model. We practically demonstrate approximate Bayesian computation (ABC)-Gibbs scheme using Kolmogorov-Smirnov as distance function ...
Mustapha Muhammad   +2 more
doaj   +1 more source

Research on the influences of location selection and permeability of wind power generation on cascading failure

open access: yesThe Journal of Engineering, 2018
The main cause for cascading failure is large-scale overload caused by localised abnormal flows. With the increase of wind power penetration, the complexity of flow distribution is strengthened.
Yang Tian   +3 more
doaj   +1 more source

Risk Assessment of a Wind Turbine: A New FMECA-Based Tool With RPN Threshold Estimation

open access: yesIEEE Access, 2020
A wind turbine is a complex system used to convert the kinetic energy of the wind into electrical energy. During the turbine design phase, a risk assessment is mandatory to reduce the machine downtime and the Operation & Maintenance cost and to ...
Marcantonio Catelani   +3 more
doaj   +1 more source

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