Results 71 to 80 of about 25,560,076 (290)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Three-dimensional internal failure propagation by spherical elastic waves in fused silica glass plate subjected to hypervelocity impact of debris

open access: yesNihon Kikai Gakkai ronbunshu, 2018
With the development of spacecraft, the brittle materials like ceramics and glass have been used for significant components especially in optical and thermal systems.
Mikio NAGANO   +4 more
doaj   +1 more source

Failure analysis of a plastic modular belt in-service [PDF]

open access: yes, 2018
[EN] In this study, an analysis of the possible causes of the failure in-service of a section of a plastic modular belt was conducted. The study begins with a reproduction of the service conditions in a traction gear. An analysis of the fracture surfaces
Sellés, M.A.   +4 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Proportion and failure analysis of full-bridge sub-modules in a hybrid MMC

open access: yesThe Journal of Engineering, 2019
Isolating DC bipolar short-circuit fault is one of the difficulties faced by the flexible DC distribution system. This study aims to the hybrid modular multi-level converter (MMC).
Yonghui Song   +3 more
doaj   +1 more source

Analysis of a failure mechanism in parabolic troughs receivers due to bellows cap overirradiation

open access: yes, 2020
Publisher Copyright: © 2020 Elsevier LtdDuring the last years the number of broken tube receivers in parabolic-trough solar collectors was higher than expected in several commercial solar power plants and the failure events increased specially in winter.
Valenzuela, Loreto   +2 more
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

An In Situ Automated System for Real-Time Monitoring of Failures in Large-Scale Field Emitter Arrays

open access: yesInstruments
Nano-scale vacuum transistors (NVCTs) based on field emission have the potential to operate at high frequencies and withstand harsh environments, such as radiation, high temperatures, and high power.
Reza Farsad Asadi   +5 more
doaj   +1 more source

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