Results 81 to 90 of about 30,256,552 (351)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Enhanced failure analysis on open TSV interconnects
, 2022 S.55-60In this paper, different methods and novel tools for failure localisation and high resolution material analysis for open TSV interconnects will be discussed.
Schmidt, C. +6 more
core
Failure analysis of a crankshaft made from ductile cast iron [PDF]
, 2006 This paper describes the failure analysis of a diesel engine crankshaft used in a truck, which is made from ductile cast iron. The crankshaft was found to break into two pieces at the crankpin portion before completion of warranty period.
Asi, Osman
core +1 more source
Reflectance Transformation Imaging as a tool for engineering failure analysis
Engineering Failure Analysis, 2019 Reflectance Transformation Imaging (RTI) is a technique which can be used to record the surface appearance of objects. It can capture a surface's interaction with incident light from different directions and it enables estimation of the surface normal ...
H. Coules, P. Orrock, C. Seow
semanticscholar +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
, 2022 Top hammer drilling is a common method to drill holes in rock formations in mining and civil engineering applications. Failure of drilling machine components has a significant impact on the cost and period of the operation.
Reza Karimi Bakhshandi +14 more
core +1 more source
The role of bridging nodes in behavioral network models of complex engineered systems
Design Science, 2018 Recent advances in early stage failure analysis approaches have introduced behavioral network analysis (BNA), which applies a network-based model of a complex engineered system to detect the system-level effect of ‘local’ failures of design variables and
Hannah S. Walsh +2 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source