Results 41 to 50 of about 1,060,769 (255)
Confined granular packings: structure, stress, and forces
, 2003 The structure and stresses of static granular packs in cylindrical containers are studied using large-scale discrete element molecular dynamics simulations in three dimensions.
A.M. Sanad +32 more
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Crack phase-field modeling of anisotropic rupture in fibrous soft tissues [PDF]
, 2017 The estimation of rupture in fibrous soft tissues has emerged as a central task in medical monitoring and risk assessment of diseases such as aortic dissection and aneurysms.
Dal, H., Gültekin, O., Holzapfel, G.A.
core
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Fracture analysis of surface and through cracks in cylindrical pressure vessels [PDF]
A previously developed fracture criterion was applied to fracture data for surface- and through-cracked cylindrical pressure vessels to see how well the criterion can correlate fracture data.
Newman, J. C., Jr.
core +1 more source
And so on: two theories of regress arguments in philosophy [PDF]
, 2013 This PhD dissertation is on infinite regress arguments in philosophy. Its main goals are to explain what such arguments from many distinct philosophical debates have in common, and to provide guidelines for using and evaluating them.
Wieland, Jan Willem
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Failure criterion of glass fabric reinforced plastic laminates [PDF]
Failure criteria are derived for several modes of failure (in unaxial tensile or compressive loading, or biaxial combined tensile-compressive loading) in the case of closely woven plain fabric, coarsely-woven plain fabric, or roving glass cloth ...
Haga, O., Hayashi, N., Kasuya, K.
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source