Results 171 to 180 of about 8,216,509 (304)

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Machine learning boosts wind turbine efficiency with smart failure detection and strategic placement. [PDF]

Sci Rep
Raju SK, Periyasamy M, Alhussan AA, Kannan S, Raghavendran S, El-Kenawy EM.   +5 more
europepmc   +1 more source

Improving Accuracy of Heart Failure Detection Using Data Refinement. [PDF]

Entropy (Basel), 2020
Xiong J, Liang X, Zhao L, Lo B, Li J, Liu C.   +5 more
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Automated ventricular segmentation and shunt failure detection using convolutional neural networks. [PDF]

Sci Rep
Huang KT, McNulty J, Hussein H, Klinger N, Chua MMJ, Ng PR, Chalif J, Mehta NH, Arnaout O.   +8 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Development of a Real-time Force-based Algorithm for Infusion Failure Detection. [PDF]

J Diabetes Sci Technol
Blanco LE, Wilcox JH, Hughes MS, Lal RA.
europepmc   +1 more source

Protocol Failure Detection: The Conflation of Acute Respiratory Distress Syndrome, SARS-CoV-2 Pneumonia and Respiratory Dysfunction.

J Emerg Trauma Shock, 2021
Lynn LA, Wheeler E, Woda R, Levitov AB, Stawicki SP, Bahner DP.   +5 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Artificial intelligence-assisted automated heart failure detection and classification from electronic health records. [PDF]

ESC Heart Fail
Oo MM, Gao C, Cole C, Hummel Y, Guignard-Duff M, Jefferson E, Hare J, Voors AA, de Boer RA, Lam CSP, Mordi IR, Tromp J, Lang CC.   +12 more
europepmc   +1 more source