Results 111 to 120 of about 7,431,248 (353)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Scientific ReportsThe biaxial compression experiments of rock-like materials with two flaws are carried out under different flaw inclination angle, rock bridge ligament angle, lateral stress. The experimental studies show that crack propagation modes of rock-like material
Shuailong Lian +4 more
doaj +1 more source
Quality Control of Knitting Process with 4QC Tools and Failure Mode and Effect Analysis (FMEA)
, 2022 Dwi Adi Sucipto, Dene Herwanto
openalex +2 more sources
A compressive failure model for anisotropic plates with a cutout under compressive and shear loads [PDF]
Failure models for the prediction of compressive strength of plates with a hole are investigated. One of the models is based on the strength failure of the fibers that leads to fiber kinking failure. A different version is developed for cases where shear
Guerdal, Zafer, Haftka, Raphael T.
core +1 more source
Patent Reform and Best Mode: A Signal to the Patent Office or a Step Toward Elimination? [PDF]
, 2012 On September 16, 2011, President Obama signed the America Invents Act (AIA), the first major overhaul of the patent system in nearly sixty years. This article analyzes the recent change to patent law\u27s best mode requirement under the AIA.
Vacca, Ryan G.
core +2 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Observations of fatigue crack nucleation and early growth are presented. The state of stress/strain was shown to play a significant role in this process.
Socie, Darrell
core +1 more source
TREX1, a predator for treating MSI‐H tumors?
Molecular Oncology, EarlyView.Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya +2 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
DISTANCIAS A LOS EXTREMOS EN CONEXIONES PERNADAS DE MADERA
Revista EIAEn este artículo se estudia la influencia de las distancias a los extremos en la aparición de concentraciones de tensiones en las conexiones pernadas de madera.
Beatriz Adela Echavarría López +1 more
doaj