Results 121 to 130 of about 1,671,563 (312)

Shaking table model test and numerical analysis of the steeply dipping bedded rock slopes under seismic actions

Scientific Reports
Based on large-scale shaking table model tests and the particle flow code PFC2D, this study investigates the failure characteristics of steeply dipping bedding rock slopes and the failure modes of the slope’s locking sections under seismic dynamic ...
Chuang Wang, Peipei Zhang, Jinyu Dong, Lingchao Meng, Leicheng Li, Mengzi Li   +5 more
doaj   +1 more source

Mixed-mode cyclic debonding of adhesively bonded composite joints [PDF]

A combined experimental-analytical investigation to characterize the cyclic failure mechanism of a simple composite-to-composite bonded joint is conducted.
Mall, S., Rezaizadeh, M. A.
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Analyzing multi-mode and multi-position reliability of composite reinforced plate based on branch-bound method

Xibei Gongye Daxue Xuebao
To overcome the concurrency of multi-mode and multi-position failures of composite structures, this paper explores the application of the branch-bound method (BBM) to the multi-mode and multi-position reliability analysis and combines the Monte Carlo ...
FENG Yunwen, SONG Zhicen, CAO Yizhe, LU Cheng, XUE Xiaofeng   +4 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Interlaminar shear stress effects on the postbuckling response of graphite-epoxy panels [PDF]

The influence of shear flexibility on overall postbuckling response was assessed, and transverse shear stress distributions in relation to panel failure were examined.
Engelstad, S. P., Knight, N. F., Jr., Reddy, J. N.   +2 more
core   +1 more source

Mechanical characteristics of carbon fibre yacht masts [PDF]

, 1995
This paper provides a preliminary stress analysis of a carbon reinforced layered cylinder such as would be found in a yacht mast. The cylinder is subjected to a compressive load and both an analytical and numerical analysis of the resulting stress fields
Blicblau, A., Clements, D.
core  

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Discrete element analysis on granular material of flow mobility characteristics under the extraterrestrial environment: insight from column collapse test

Yantu gongcheng xuebao
With the increasing interest of countries in deep space exploration, investigating the effect of extraterrestrial environment on the flow mobility and failure mode of granular column collapse, has a vital guiding significance for in-situ resource ...
SHI Anning 1, 2, JIANG Mingjing 3, YANG Gengchao 4, KWOK Chungyee 5, WANG Siyuan 1, LIN Jiayu 1
doaj   +1 more source