Results 111 to 120 of about 1,671,563 (312)

Research on the Punching Shear Performance of Steel Grid–UHPC Composite Bridge Decks

Buildings
This study conducted punching shear tests on steel grid–ultra-high-performance concrete (UHPC) composite bridge decks and performed finite element analysis (FEA) to evaluate their punching shear performance. Initially, a comparative analysis is conducted
Sumei Liu, Peng Wang, Pengfei Ren, Hanshan Ding   +3 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Audit Laporan Failure Mode and Effect Analysis (Fmea) Produk Ga Rear Motor Wiper Berdasarkan Objektif Kualitas Pada PT. Xyz [PDF]

, 2015
PT XYZ using FMEA report GA Rear Wiper which is adopted from PT XYZ Jepang and they has not made the adjustment to the condition in the production floor. This cause will create the failure process that can be evaluated from the percentage of defect.
Kumala, A. (Amelia), Rumita, R. (Rani)
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Tensile failure and ductile-to-brittle transition of sandstone under three-dimensional seepage pressure

Rock Mechanics Bulletin
After reservoir impoundment, fractures and pores in the rock mass serve as important pathways for seepage, and the resulting fluid pressure can easily trigger engineering issues such as slope instability and dam deformation. To investigate the mechanical
Xiang Fu, Kecheng Ji, Aiqing Wu, Qiang Xie, Yuxin Ban   +4 more
doaj   +1 more source

Space tug propulsion system failure mode, effects and criticality analysis [PDF]

For purposes of the study, the propulsion system was considered as consisting of the following: (1) main engine system, (2) auxiliary propulsion system, (3) pneumatic system, (4) hydrogen feed, fill, drain and vent system, (5) oxygen feed, fill, drain ...
Boyd, J. W., Hardison, E. P., Heard, C. B., Orourke, J. C., Osborne, F., Wakefield, L. T.   +5 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

The Failure Mode Theorem

Across multiple foundational domains—axiomatic mathematics, general relativity, and quantum mechanics—decades of sustained theoretical effort have yielded extraordinary internal development without corresponding resolution of core conceptual impasses.
openaire   +3 more sources

Application of failure mode and effect analysis in medication management in emergency infusion room

Huli yanjiu, 2016
Objective:To probe into the application effect of failure mode and effect analysis (FMEA) for medication management in emergency infusion room.Methods:The risk factors in the process of medication in emergency infusion room were analyzed by failure mode ...
WANG Haiyan, Li Hongfang, Sha Ling
doaj