Results 141 to 150 of about 271,979 (304)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Use of failure mode and effect analysis to reduce patient safety risks in purchasing prescription drugs from online pharmacies in China. [PDF]

Front Med (Lausanne), 2022
Hu Q, Hu H, Hu M, Zhang J, Gou L, Shi S, Zhou J, Zhou N, Huang Z.   +8 more
europepmc   +1 more source

Numerical analysis of effect of cohesive parameters on mixed-mode failure of double-scarf adhesive joint subjected to uniaxial tensile loadings

, 2015
In the present study, the effects of cohesive parameters on the mixed-mode failure of double-scarf adhesive joint (DSAJ) subjected to uniaxial tensile loadings were examined and discussed numerically.
Liao LJ(廖丽涓), ljl@imech.ac.cn, Huang CG(黄晨光), huangcg@imech.ac.cn   +3 more
core  

REDESIGN PELAYANAN FARMASI DENGAN METODE FAILURE MODE AND EFFECT ANALYSIS

, 2013
Background: Pharmacy service is a high risk area in thesupport of health service quality. PKU Muhammadiyah Hospitalis a hospital that respons to systematic movement in servicesthat focus on patient safety such as minimizing the incidenceof medication ...
Kristin, Erna, Djasri, Hanevi, Supriyanti, Eri   +2 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Production risk management of prawn crackers using fuzzy FMEA and fuzzy AHP methods

Advances in Food Science, Sustainable Agriculture, and Agroindustrial Engineering
Prawn crackers hold a significant position within Indonesia's agro-industrial product landscape. The industrial process involved in their production is fraught with potential risks that could result in substantial losses for companies. PT.
Sri Dharma Cyntya Atmaka, Imam Santoso, Wike Agustin Prima Dania   +2 more
doaj   +1 more source

Failure Mode and Effect Analysis: Engineering Safer Neurocritical Care Transitions. [PDF]

Neurocrit Care, 2021
Chilakamarri P, Finn EB, Sather J, Sheth KN, Matouk C, Parwani V, Ulrich A, Davis M, Pham L, Chaudhry SI, Venkatesh AK.   +10 more
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Identifying risk characteristics using failure mode and effect analysis for risk management in online magnetic resonance-guided adaptive radiation therapy. [PDF]

Phys Imaging Radiat Oncol, 2022
Nishioka S, Okamoto H, Chiba T, Sakasai T, Okuma K, Kuwahara J, Fujiyama D, Nakamura S, Iijima K, Nakayama H, Takemori M, Tsunoda Y, Kaga K, Igaki H.   +13 more
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source