Results 121 to 130 of about 4,436,913 (350)
Failure-rate computations based on Mariner Mars 1969 spacecraft data [PDF]
An analysis of in-flight spacecraft part hours and failure data from the Mariner Mars 1969 Project is given. It contains failure rates computed from this data for all electronic and electromagnetic parts on the Mariners 6 and 7 spacecraft.
Chelson, P. O.
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
CONGENITAL FAILURE OF AUTOMATIC CONTROL OF VENTILATION GASTROINTESTINAL HOTILITY, AND HEART RATE [PDF]
, 1977 Gabriel G. Haddad +6 more
openalex +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
The new generalized inverse Weibull distribution
پژوهشهای ریاضی, 2015 Failure rate is one of the important concepts in reliability theory. In this paper, we introduce a new distribution function containing four parameters based on inverse Weibull distribution.
A Dostmoradi, M Zadkarami, V Bahrami
doaj
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
TREX1, a predator for treating MSI‐H tumors?
Molecular Oncology, EarlyView.Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya +2 more
wiley +1 more source
The financial sustainability of Microcredit in Portugal [PDF]
Microcredit and microfinance emerged in the 1970’s in Bangladesh and other developing countries and expanded rapidly worldwide as a business model financially sustainable and able to fight poverty and social exclusion.
Isabel G Mota +2 more
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