Results 31 to 40 of about 190,306 (282)

Value Alignment, Fair Play, and the Rights of Service Robots

open access: yes, 2018
Ethics and safety research in artificial intelligence is increasingly framed in terms of "alignment" with human values and interests. I argue that Turing's call for "fair play for machines" is an early and often overlooked contribution to the alignment ...
Estrada, Daniel
core   +1 more source

A PRSZT Registry Analysis of Prognostic Factors Influencing Survival and Relapse Rates After Second Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Acute Lymphoblastic Leukemia

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT A second allogeneic (allo‐)hematopoietic stem cell transplantation (HSCT2) is a potential curative option for pediatric patients with acute lymphoblastic leukemia (ALL) following relapse after first allogeneic transplantation (HSCT1), but its efficacy is limited by high relapse rates and transplant‐related toxicity in highly pretreated ...
Ava Momm   +10 more
wiley   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Socjalizująca rola aktywności sportowej dzieci i młodzieży w świetle współczesnej literatury socjologicznej i humanistycznej

open access: yesRozprawy Społeczne, 2020
W artykule podjęto analizę wybranych kilkudziesięciu dzieł współczesnych socjologów i teoretyków sportu i humanistów (publikacje książkowe i artykuły), którzy rozważali rolę sportu w socjalizacji dzieci i młodzieży we współczesnym świecie.
Ryszard Polak, Paweł Tarkowski
doaj   +1 more source

Free riders play fair [PDF]

open access: yes, 2012
After the demise of the social contract theory, the argument from fair play, which employs the principle of fair play, has been widely acknowledged as one of the most promising ways of justifying political obligation.
Takikawa, Hirohide
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Keefektifan Hadiah Fair Play terhadap Sportivitas, Fair Play dan Karakter Permainan Sepak Bola U12 [PDF]

open access: yes, 2012
Penelitian ini bertujuan untuk mengetahui keefektifan hadiah fair play terhadap sportivitas, fair play dan karakter dalam permainan sepak bola. Perilaku sportivitas diamati pada menghormati pemain lawan dan menghormati wasit.
Sugiharto, Wachid
core  

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