Results 71 to 80 of about 128,780 (252)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Fair Play: Application of Normalized Scoring to Emergency Department Throughput Quality Measures in a National Registry. [PDF]
Ann Emerg Med, 2021 Venkatesh A +7 more
europepmc +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Social-regulavive concept «fair play» in english linguaculture
Russian journal of linguistics: Vestnik RUDN, 2009 Linguacultural social-regulative concept «fair play» is analized in the article. The concept contains moral-ethic values (the highest orientations) and norms of behaviour.
L A Gunina
doaj
Sustainability in the football industry: An approach to the gap between theoretical formulation and practical application, through the results of the social fair play project. [PDF]
Heliyon, 2021 Fernández-Villarino R.
europepmc +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa +2 more
wiley +1 more source
Development of human monoclonal antibodies against TARM1 by yeast display
FEBS Open Bio, EarlyView.Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe +5 more
wiley +1 more source
Identification and evaluation of fair play behaviors in juvenile football Cadiz
E-balonmano.com: Revista de Ciencias del Deporte, 2014 Objective: To analyse sportsmanlike and unsportsmanlike conduct of football players in juvenile category (aged from 10-12), as well as sanctioning of players and their trainers.
Javier Lamoneda Prieto +3 more
doaj +2 more sources
ROLE OF SPORT ACTIVITIES IN THE FORMATION OF ETICHO-MORAL VALUES
Sport şi Societate, 2012 Moral values play an essential role in the orientation of UMA, us, in setting the objectives and goals to be attained, the strategies and ways of action; they, the matter shall be referred to states or modes of action, siderate cone to be delisted ...
Popescu V.
doaj