Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Las manifestaciones del juego limpio en el ejercicio de la actividad cinegética
Revista Vasca de Administración Pública, 2011 From yesteryear, there are a collection of rules which make up the action of hunting with the scope of protecting a scenario where the hunters¿ advantage is not to be superior as making the animal impossible or very difficult to get away from the tights ...
José María Pérez Monguió
doaj +1 more source
The Open Sore of Football: Aggressive Violent Behavior and Hooliganism
Physical Culture and Sport: Studies and Research, 2016 Aggression and violence have been a customary part of life that mankind has had to live with from the beginning of time; it has been accepted by society even though it expresses endless negativity.
Gumusgul Osman, Acet Mehmet
doaj +1 more source
Fair Play in Professional Sports: Sportspersonship Orientations of Futsal Players [PDF]
, 2014 El objetivo de este estudio es identificar las orientaciones de los jugadores de fútbol sala profesional ' en cuatro definiciones de deportividad . Las orientaciones de los jugadores de fútbol sala profesionales en deportividad fueron identificados a ...
Sezen-Balçikanli, Gülfem
core
Is gene doping going to change the sports law? [PDF]
, 2017 From time to time the public is informed about the start of the sporting struggles. Championship, Olympics, qualifications and eliminations are events that have become part of individual media centers programs. For many years, during such events there is
Kmieciak, Błażej
core +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Fair play i kroppsøvingsfaget i lys av aristotelisk dydsetikk
Etikk i Praksis: Nordic Journal of Applied Ethics, 2013 Artikkelen ønsker å gi et konstruktivt bidrag til forståelsen og anvendelsen av fair play i en kroppsøvingsfaglig kontekst. Dette er et tema som er blitt aktualisert i og med at fair play er kommet inn som et sentralt element i kroppsøvingsfagets nye ...
Ove Ronny Olsen Sæle
doaj +1 more source
Moral Identity and Attitudes towards Doping in Sport: Whether Perception of Fair Play Matters. [PDF]
Int J Environ Res Public Health, 2021 Sukys S +3 more
europepmc +1 more source
DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling
FEBS Open Bio, EarlyView.Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang +7 more
wiley +1 more source
Fair play? Participation equity in organised sport and physical activity among children and adolescents in high income countries: a systematic review and meta-analysis. [PDF]
Int J Behav Nutr Phys Act, 2022 Owen KB +7 more
europepmc +1 more source