Results 71 to 80 of about 1,004,733 (299)

How are we FAIR-ing? Creating a FAIR self-assessment checklist for data repositories

IASSIST Quarterly
In 2023, a team from a local grant-funded medical data repository requested guidance from Penn Libraries on evaluating the extent to which their repository was FAIR-enabling.
Lauren Phegley, Lynda Kellam
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

A new version of the binary star database BDB: Challenges and directions

Open Astronomy, 2023
In accordance with the principles of open science, the results of the research should remain available for further investigations and practical interaction with them in the research community.
Kaygorodov Pavel, Skvortsov Nikolay, Kovaleva Dana, Malkov Oleg   +3 more
doaj   +1 more source

Public Preferences about Fairness and the Ethics of Allocating Scarce Medical Interventions [PDF]

, 2017
This chapter examines how social- scientific research on public preferences bears on the ethical question of how those resources should in fact be allocated, and explain how social-scientific researchers might find an understanding of work in ethics ...
Persad, Govind
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

FAIR-Aware: Assess your knowledge on the FAIR data principles

, 2021
This session was part of the NWO Life2021 Congress workshop "Plan ahead: practical tools to make your data and software more FAIR" held on 27 May 2021 on Zoom. https://doi.org/10.5281/zenodo.4817608 In this session, the FAIR-Aware tool was introduced and the use of the tool was discussed in depth with the example of one of the questions.
openaire   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

From representing views to representativeness of views: illustrating a new (Q2S) approach in the context of health care priority setting in nine European countries [PDF]

, 2016
Governments across Europe are required to make decisions about how best to allocate scarce health care resources. There are legitimate arguments for eliciting societal vales in relation to health care resource allocation given the roles of the general ...
Adam Kozierkiewicz, Andrea Manca, Angela Robinson, Annika Bergman, Awad Mataria, Cam Donaldson, Cam Donaldson, Christel Protière, Darek Poznanski, Dorte Gyrd-Hansen, Emily Lancsar, Ewa Kocot, Helen Mason, Helen Mason, Jan Abel Olsen, Jean Paul Moatti, Job van Exel, Job van Exel, John Wildman, Jose Luis Pinto Prades, Jytte Seested Nielsen, László Gulácsi, Mark Pennington, Michael Jones-Lee, Mickael Beck, Márta Péntek, Phil Shackley, Philomena Bacon, Rachel Baker, Rachel Baker, Rana Khatib, Roman Topór-Madry, Samer Kharroubi, Stephane Luchini, Sue Bell, Trine Kjaer, Ulf Persson, Werner Brouwer, Werner Brouwer, Yara Jaralla   +39 more
core   +5 more sources

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Features of a FAIR vocabulary

Journal of Biomedical Semantics, 2023
Background The Findable, Accessible, Interoperable and Reusable(FAIR) Principles explicitly require the use of FAIR vocabularies, but what precisely constitutes a FAIR vocabulary remains unclear.
Fuqi Xu, Nick Juty, Carole Goble, Simon Jupp, Helen Parkinson, Mélanie Courtot   +5 more
doaj   +1 more source