Results 61 to 70 of about 1,676,158 (297)
Basically the work consists of the denial of a claim, which is largely entrenched in doctrine, according to which lex sportiva represents a transnational or non-national legal system, on the one hand, and affirmation of fair-play, as the principle that ...
Miodrag Mićović
doaj
Conflicting Views on Fair Siting Processes: Evidence from Austria and the U.S. [PDF]
The authors maintain that, by granting legitimacy to different notions of fairness and building on common values such as responsibility, it is possible to design siting procedures that promote social cohesion, trust and a sense of fair ...
Fitzgerald, Kevin B. +1 more
core +1 more source
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
British fair play: sport across diasporas at the BBC World Service [PDF]
This chapter uses archive material to explore the role of sports broadcasting on the BBC World Service in the twentieth century.Whereas the service's early audiences were expatriate British listeners, the BBC WS recruited different diasporic audiences ...
Goldblatt, David +2 more
core
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Education through sport with the principle of fair play in pre-war Łódź – a city of cultural differences [PDF]
The educational aspects of sports were recognized during the development of sports along with its educational values, character formation, including the adherence to the fair play principle, primarily in English schools.
Jolanta Kowalska, Piotr Kędzia
doaj +1 more source
'Plough Bullocks' and Related Plough Monday Customs in the Nottingham Area, 1800-1930 [PDF]
This paper describes Plough Monday activities in the city of Nottingham, which died out in the inter-war years, and chronicles the establishment of its Plough Day Fair in 1712.
Millington, Peter
core

