Results 61 to 70 of about 143,895 (291)
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
, 2017 Sport je društveni fenomen koji potiče društvo u cjelini. „Fair play“ je svjetski poznat koncept koji svoje porijeklo vuče iz sporta, a postala je filozofija poštovanja drugih, ali i poštovanje pravila, kako na sportskim terenima tako i u drugim ...
Tot, Marina
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E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Education through sport with the principle of fair play in pre-war Łódź – a city of cultural differences [PDF]
Studia z Teorii WychowaniaThe educational aspects of sports were recognized during the development of sports along with its educational values, character formation, including the adherence to the fair play principle, primarily in English schools.
Jolanta Kowalska, Piotr Kędzia
doaj +1 more source
, 2006 Regulations have been in place since 2003 to prevent discrimination in employment on the grounds of Sexual Orientation. However, legislation is not on its own enough to secure fair practices in the workplace.
Nunn, AE, Monro, S
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Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
, 1944 Statement regarding the Fair Play Committee's opposition to the selective service and notice of their refusal to attend the physical examination at Heart Mountain incarceration camp.The Japanese American Archival Collection documents the people, places ...
Fair Play Committee
core +1 more source
Las manifestaciones del juego limpio en el ejercicio de la actividad cinegética
Revista Vasca de Administración Pública, 2011 From yesteryear, there are a collection of rules which make up the action of hunting with the scope of protecting a scenario where the hunters¿ advantage is not to be superior as making the animal impossible or very difficult to get away from the tights ...
José María Pérez Monguió
doaj +1 more source
Pacific Coast Committee on American Principles and Fair Play, [draft]
, 1943 Document endorsing U.S. government policies including segregation of "disloyal persons of Japanese ancestry," protecting the rights of Japanese Americans to serve in the military, the ability for Japanese Americans to resettle in a way that meets the ...
Pacific Coast Committee on American Principles and Fair Play: author
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