Results 91 to 100 of about 1,341,301 (290)
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
The CARE Principles for Indigenous Data Governance
Data Science Journal, 2020 Concerns about secondary use of data and limited opportunities for benefit-sharing have focused attention on the tension that Indigenous communities feel between (1) protecting Indigenous rights and interests in Indigenous data (including traditional ...
Stephanie Russo Carroll +13 more
doaj +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
De aartsbisschop en de onpartijdige rechters [PDF]
, 2012 On fair trial principles and the impartiality of ...
Voorhoof, Dirk
core
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
Adapting FAIR Evaluation to Photon and Neutron Facilities
International Journal of Digital CurationThe FAIR principles have become essential in establishing transparent and trustworthy research practices. However the FAIR principles are guidelines indicating the features expected for data to be FAIR, and do not stipulate evaluation criteria ...
Simon Lambert +2 more
doaj +1 more source
Measuring FAIR Principles to Inform Fitness for Use
International Journal of Digital Curation, 2018 For open science to flourish, data and any related digital outputs should be discoverable and re-usable by a variety of potential consumers. The recent FAIR Data Principles produced by the Future of Research Communication and e-Scholarship (FORCE11 ...
Bradley Wade Bishop, Carolyn Hank
doaj +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Introduction – FAIR data, systems and analysis
Data Science, 2020 The FAIR principles outline key attributes to make digital resources more Findable, Accessible, Interoperable, and Reusable. Globally endorsed and widely adopted, there is now a pressing need to enable the establishment of an Internet of FAIR Data and ...
Paul Groth, Michel Dumontier
doaj +1 more source
Aging and Cancer, EarlyView.ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef +2 more
wiley +1 more source