Results 61 to 70 of about 94,617 (292)
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
THE VALUE AND ASPECTS OF THE RIGHT TO A FAIR TRIAL FROM THE PERSPECTIVE OF LEGAL SECURITY [PDF]
Legea și ViațaThe study is dedicated to the right to a fair trial, with the aim of highlighting the necessity of researching and understanding its essence, dimensions, and content to successfully strengthen the internal legal mechanism for its enforcement and ...
Irina IACUB, Gheorghe COSTACHI
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau +9 more
wiley +1 more source
Gains from no real PAINS: Where 'Fair Trial Strategy' stands in the development of multi-target ligands. [PDF]
Acta Pharm Sin B, 2021 Sun J, Zhong H, Wang K, Li N, Chen L.
europepmc +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
Compatible or incompatible?: Intelligence and human rights in terrorist trials
Amsterdam Law Forum, 2012 <span style="font-family: Times New Roman; font-size: small;"> </span><p class="MsoNormal" style="margin: 0cm 0cm 0pt;"><span style="font-family: "Garamond","serif"; font-size: 12pt; mso-ansi ...
Quirine Eijkman, Bibi van Ginkel
doaj
Trial within a reasonable time in comparative law [PDF]
Strani pravni život, 2019 The right to a trial within a reasonable time as part of the right to a fair trial is one of the fundamental human rights that belongs to all people without distinction.
Bećirović-Alić Maida M.
doaj
Utrecht Law Review, 2011 Since the adoption of the UN Convention of the Rights of the Child in 1989, the right to participation has been recognised internationally as one of the general principles of children's legal status.
Annemarieke Beijer, Ton Liefaard
doaj +1 more source
Encrochat: The hacker with a warrant and fair trials?
Forensic Science International: Digital Investigation, 2023 This paper introduces the Encrochat operation as an example of the technological, cross-border, and cross-disciplinary complexity of one contemporary digital investigation. The use of encryption for large-scale criminal activity and organized crime requires law enforcement to act pro-actively to secure evidence, to rely on cross-border evidence ...
openaire +1 more source